Towards a better understanding of QT interval variability

Larisa G. Tereshchenko, Ronald D. Berger

    Research output: Contribution to journalReview articlepeer-review

    9 Scopus citations

    Abstract

    The International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) Guideline E14 recommends ‘Thorough QT Study’ as a standard assessment of drug-induced QT interval prolongation. At the same time, the value of drug-induced QTc prolongation as a surrogate marker for risk of life-threatening polymorphic ventricular tachycardia known as torsades des pointes remains controversial. Beat-to-beat variability of QT interval was recently proposed as an alternative metric. The following review addresses mechanisms of beat-to-beat QT variability, methods of QT interval variability measurements, and its prognostic value in clinical studies.

    Original languageEnglish (US)
    Pages (from-to)245-251
    Number of pages7
    JournalTherapeutic Advances in Drug Safety
    Volume2
    Issue number6
    DOIs
    StatePublished - Dec 2011

    Keywords

    • QT interval
    • QT variability
    • drug safety
    • ventricular tachyarrhythmias

    ASJC Scopus subject areas

    • Pharmacology (medical)

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