Total pancreatectomy with islet autotransplantation summary of a national institute of diabetes and digestive and kidney diseases workshop

Melena D. Bellin, Andres Gelrud, Guillermo Arreaza-Rubin, Ty B. Dunn, Abhinav Humar, Katherine A. Morgan, Bashoo Naziruddin, Cristiana Rastellini, Michael R. Rickels, Sarah J. Schwarzenberg, Dana K. Andersen

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

A workshop sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases focused on research gaps and opportunities in total pancreatectomy with islet autotransplantation (TPIAT) for the management of chronic pancreatitis (CP). The session was held on July 23, 2014, and structured into 5 sessions: (1) patient selection, indications, and timing; (2) technical aspects of TPIAT; (3) improving success of islet autotransplantation; (4) improving outcomes after total pancreatectomy; and (5) registry considerations for TPIAT. The current state of knowledge was reviewed; knowledge gaps and research needs were specifically highlighted. Common themes included the need to identify which patients best benefit from and when to intervene with TPIAT, current limitations of the surgical procedure, diabetes remission and the potential for improvement, opportunities to better address pain remission, gastrointestinal complications in this population, and unique features of children with CP considered for TPIAT. The need for a multicenter patient registry that specifically addresses the complexities of CP and total pancreatectomy outcomes as well as postsurgical diabetes outcomes was repeatedly emphasized.

Original languageEnglish (US)
Pages (from-to)1163-1170
Number of pages8
JournalPancreas
Volume43
Issue number8
DOIs
StatePublished - Nov 10 2014

Keywords

  • Chronic pancreatitis
  • Diabetes
  • Islet transplantation
  • Pain
  • Pancreatectomy
  • Pancreatic exocrine insufficiency

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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    Bellin, M. D., Gelrud, A., Arreaza-Rubin, G., Dunn, T. B., Humar, A., Morgan, K. A., Naziruddin, B., Rastellini, C., Rickels, M. R., Schwarzenberg, S. J., & Andersen, D. K. (2014). Total pancreatectomy with islet autotransplantation summary of a national institute of diabetes and digestive and kidney diseases workshop. Pancreas, 43(8), 1163-1170. https://doi.org/10.1097/mpa.0000000000000236