Torsion dynamics in the evolution from acute to chronic mitral regurgitation

Frederick (Fred) Tibayan, Kwok L. Yun, David T M Lai, Tomasz A. Timek, George T. Daughters, Neil B. Ingels, D. Craig Miller

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background and aim of study: Left ventricular (LV) torsion reduces transmural fiber strain gradients during systole, and torsional recoil in early diastole is thought to assist LV filling. To test the hypothesis that deterioration of torsional dynamics accompanied LV dysfunction during the evolution of mitral regurgitation (MR), torsion was measured during the progression from acute to chronic MR in a canine model. Methods: Seven dogs underwent cardiopulmonary bypass for LV marker placement and creation of MR by disrupting the posterior leaflet. After 7-10 days, three-dimensional marker coordinates were measured with biplane videofluoroscopy to study LV geometry, size and function, plus maximal torsional deformation, time of maximal torsion relative to end-ejection, and early diastolic torsional recoil during the first 5% of filling. After three months, the animals were re-studied. Results: Progression from acute to chronic MR was associated with a significant decrease in maximum LV dP/dt (1,574 ± 213 to 1,300 ± 252 mmHg/s, p

Original languageEnglish (US)
Pages (from-to)39-46
Number of pages8
JournalJournal of Heart Valve Disease
Volume11
Issue number1
StatePublished - Jan 2002
Externally publishedYes

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Mitral Valve Insufficiency
Diastole
Systole
Left Ventricular Dysfunction
Cardiopulmonary Bypass
Canidae
Dogs

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Tibayan, F. F., Yun, K. L., Lai, D. T. M., Timek, T. A., Daughters, G. T., Ingels, N. B., & Miller, D. C. (2002). Torsion dynamics in the evolution from acute to chronic mitral regurgitation. Journal of Heart Valve Disease, 11(1), 39-46.

Torsion dynamics in the evolution from acute to chronic mitral regurgitation. / Tibayan, Frederick (Fred); Yun, Kwok L.; Lai, David T M; Timek, Tomasz A.; Daughters, George T.; Ingels, Neil B.; Miller, D. Craig.

In: Journal of Heart Valve Disease, Vol. 11, No. 1, 01.2002, p. 39-46.

Research output: Contribution to journalArticle

Tibayan, FF, Yun, KL, Lai, DTM, Timek, TA, Daughters, GT, Ingels, NB & Miller, DC 2002, 'Torsion dynamics in the evolution from acute to chronic mitral regurgitation', Journal of Heart Valve Disease, vol. 11, no. 1, pp. 39-46.
Tibayan FF, Yun KL, Lai DTM, Timek TA, Daughters GT, Ingels NB et al. Torsion dynamics in the evolution from acute to chronic mitral regurgitation. Journal of Heart Valve Disease. 2002 Jan;11(1):39-46.
Tibayan, Frederick (Fred) ; Yun, Kwok L. ; Lai, David T M ; Timek, Tomasz A. ; Daughters, George T. ; Ingels, Neil B. ; Miller, D. Craig. / Torsion dynamics in the evolution from acute to chronic mitral regurgitation. In: Journal of Heart Valve Disease. 2002 ; Vol. 11, No. 1. pp. 39-46.
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