Topical treatments of laparoscopic port sites can decrease the incidence of incision metastasis

N. Eshraghi, L. L. Swanstrom, T. Bax, B. Jobe, K. Horvath, Brett Sheppard, Clifford Deveney

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Background: Antecdotal reports of port site tumor recurrence have dampened the enthusiasm for laparoscopic colectomy for cancer. We developed a rat model that creates a high incidence of port site metastasis following laparoscopic intervention. Our goal was to assess the feasibility of minimizing implantations using port site irrigation prior to wound closure. Methods: Colon cancer carcinomatosis was established in 46 female BD9 rats using intraperitoneal injections of 106 DHD-K12-TRb rat colon cancer cells. This preparation yielded an 81% incidence of port site metastasis in a control group. Laparoscopic sham surgery was performed using four ports and a CO2 pneumoperitoneum. Four treatment groups were studied by irrigating each port site as follows: Group I, sterile water; group II, normal saline; group III, heparin; group IV, 5-flurouracil (5-FU). The animals were killed at 4 weeks, and the port sites were examined for tumors. Results: There were no differences in port site metastasis between controls and groups I, II, and III. The 5-FU group showed a significant decrease (30% vs 81%) in metastasis. Conclusions: Port site irrigation with 5-FU at the time of laparoscopy reduces the incidence of port site tumor implantation in a rat colon cancer model. This finding may have utility in patients at high risk of such metastasis who undergo laparoscopy for colon cancer.

Original languageEnglish (US)
Pages (from-to)1121-1124
Number of pages4
JournalSurgical Endoscopy and Other Interventional Techniques
Volume13
Issue number11
DOIs
StatePublished - Nov 1999

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Colonic Neoplasms
Neoplasm Metastasis
Laparoscopy
Incidence
Neoplasms
Therapeutics
Control Groups
Pneumoperitoneum
Colectomy
Intraperitoneal Injections
Heparin
Carcinoma
Recurrence
Water
Wounds and Injuries

Keywords

  • Colectomy
  • Colon cancer
  • Laparoscopy
  • Metastasis
  • Wound recurrence

ASJC Scopus subject areas

  • Surgery

Cite this

Topical treatments of laparoscopic port sites can decrease the incidence of incision metastasis. / Eshraghi, N.; Swanstrom, L. L.; Bax, T.; Jobe, B.; Horvath, K.; Sheppard, Brett; Deveney, Clifford.

In: Surgical Endoscopy and Other Interventional Techniques, Vol. 13, No. 11, 11.1999, p. 1121-1124.

Research output: Contribution to journalArticle

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abstract = "Background: Antecdotal reports of port site tumor recurrence have dampened the enthusiasm for laparoscopic colectomy for cancer. We developed a rat model that creates a high incidence of port site metastasis following laparoscopic intervention. Our goal was to assess the feasibility of minimizing implantations using port site irrigation prior to wound closure. Methods: Colon cancer carcinomatosis was established in 46 female BD9 rats using intraperitoneal injections of 106 DHD-K12-TRb rat colon cancer cells. This preparation yielded an 81{\%} incidence of port site metastasis in a control group. Laparoscopic sham surgery was performed using four ports and a CO2 pneumoperitoneum. Four treatment groups were studied by irrigating each port site as follows: Group I, sterile water; group II, normal saline; group III, heparin; group IV, 5-flurouracil (5-FU). The animals were killed at 4 weeks, and the port sites were examined for tumors. Results: There were no differences in port site metastasis between controls and groups I, II, and III. The 5-FU group showed a significant decrease (30{\%} vs 81{\%}) in metastasis. Conclusions: Port site irrigation with 5-FU at the time of laparoscopy reduces the incidence of port site tumor implantation in a rat colon cancer model. This finding may have utility in patients at high risk of such metastasis who undergo laparoscopy for colon cancer.",
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AU - Sheppard, Brett

AU - Deveney, Clifford

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