Topical therapy of alopecia areata with squaric acid dibutylester

P. C. Case, A. J. Mitchell, Neil Swanson, E. E. Vanderveen, C. N. Ellis, J. T. Headington

Research output: Contribution to journalArticle

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Abstract

The efficacy of the topical allergen squaric acid dibutylester (SADBE) was investigated in the treatment of twenty-six patients with alopecia areata or alopecia totalis. The patients had their disease for a mean duration of 8.3 years (range, 3 months to 27 years). Sensitization was attempted with 2% SADBE in acetone. Five individuals could not be sensitized. The twenty-one sensitized patients were treated with topical applications of 0.001% to 1.0% SADBE in acetone adjusted to produce and maintain dermatitis for an average of 21 weeks. Eleven (52%) had excellent responses consisting of complete regrowth in six and cosmetically acceptable regrowth in five. The average treatment time for regrowth was 11 weeks (range, 5-20 weeks). Ten (48%) had no clinical response after an average of 19 weeks of therapy (range, 4-42 weeks). Topical SADBE is an effective therapy for some patients with long-standing alopecia areata.

Original languageEnglish (US)
Pages (from-to)447-451
Number of pages5
JournalJournal of the American Academy of Dermatology
Volume10
Issue number3
DOIs
StatePublished - 1984
Externally publishedYes

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Alopecia Areata
Acetone
Alopecia
Dermatitis
Therapeutics
Allergens
squaric acid

ASJC Scopus subject areas

  • Dermatology

Cite this

Case, P. C., Mitchell, A. J., Swanson, N., Vanderveen, E. E., Ellis, C. N., & Headington, J. T. (1984). Topical therapy of alopecia areata with squaric acid dibutylester. Journal of the American Academy of Dermatology, 10(3), 447-451. https://doi.org/10.1016/S0190-9622(84)80091-2

Topical therapy of alopecia areata with squaric acid dibutylester. / Case, P. C.; Mitchell, A. J.; Swanson, Neil; Vanderveen, E. E.; Ellis, C. N.; Headington, J. T.

In: Journal of the American Academy of Dermatology, Vol. 10, No. 3, 1984, p. 447-451.

Research output: Contribution to journalArticle

Case, PC, Mitchell, AJ, Swanson, N, Vanderveen, EE, Ellis, CN & Headington, JT 1984, 'Topical therapy of alopecia areata with squaric acid dibutylester', Journal of the American Academy of Dermatology, vol. 10, no. 3, pp. 447-451. https://doi.org/10.1016/S0190-9622(84)80091-2
Case, P. C. ; Mitchell, A. J. ; Swanson, Neil ; Vanderveen, E. E. ; Ellis, C. N. ; Headington, J. T. / Topical therapy of alopecia areata with squaric acid dibutylester. In: Journal of the American Academy of Dermatology. 1984 ; Vol. 10, No. 3. pp. 447-451.
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