Topical therapeutic efficacy of 9-(2-hydroxyethoxymethyl)guanine and 5-iodo-5'-amino-2',5'-dideoxyuridine on oral infection with herpes simplex virus in mice

N. H. Park, D. Pavan-Langston, M. E. Hettinger, S. L. McLean, Daniel Albert, T. S. Lin, W. H. Prusoff

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The therapeutic efficacy of two new antiviral agents, 5-iodo-5'-amino-2', 5'-dideoxyuridine (AIdUrd) and 9-(2-hydroxyethoxymethyl)guanine (ACV), in the model of mouse lip inoculated with herpes simplex virus type 2 is reported. The effects on development of clinical lesions, viral replication in the inoculated lips, and establishment of latent viral infection in the trigeminal ganglia were observed. The earlier the treatment with AIdUrd and ACV was initiated after inoculation, the better was the chemotherapeutic effect. AIdUrd and ACV treatment, when initiated 48 and 72 hr after inoculation, respectively, showed no chemotherapeutic efficacy. Establishment of viral latent infection sensory ganglia was significantly prevented only when ACV treatment was initiated very early (1 or 3 hr) after inoculation. The results indicate that both drugs have significant antiviral activity, in part dependent on the time of initiation of therapy, and that ACV is superior to AIdUrd as a topical agent for therapy of herpes simplex virus type 2 infections.

Original languageEnglish (US)
Pages (from-to)575-579
Number of pages5
JournalJournal of Infectious Diseases
Volume141
Issue number5
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

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Guanine
Simplexvirus
Virus Diseases
Human Herpesvirus 2
Lip
Infection
Antiviral Agents
Sensory Ganglia
Trigeminal Ganglion
Therapeutics
AIdUrd
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Topical therapeutic efficacy of 9-(2-hydroxyethoxymethyl)guanine and 5-iodo-5'-amino-2',5'-dideoxyuridine on oral infection with herpes simplex virus in mice. / Park, N. H.; Pavan-Langston, D.; Hettinger, M. E.; McLean, S. L.; Albert, Daniel; Lin, T. S.; Prusoff, W. H.

In: Journal of Infectious Diseases, Vol. 141, No. 5, 01.01.1980, p. 575-579.

Research output: Contribution to journalArticle

Park, N. H. ; Pavan-Langston, D. ; Hettinger, M. E. ; McLean, S. L. ; Albert, Daniel ; Lin, T. S. ; Prusoff, W. H. / Topical therapeutic efficacy of 9-(2-hydroxyethoxymethyl)guanine and 5-iodo-5'-amino-2',5'-dideoxyuridine on oral infection with herpes simplex virus in mice. In: Journal of Infectious Diseases. 1980 ; Vol. 141, No. 5. pp. 575-579.
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