TY - JOUR
T1 - Topical antimicrobial treatment of acne vulgaris
T2 - An evidence-based review
AU - Gamble, Ryan
AU - Dunn, Jeff
AU - Dawson, Annelise
AU - Petersen, Brian
AU - McLaughlin, Lauren
AU - Small, Alison
AU - Kindle, Scott
AU - Dellavalle, Robert P.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2012
Y1 - 2012
N2 - Topical antimicrobial treatment is indicated for mild to moderate acne vulgaris. Our literature review includes searches of Ovid, MEDLINE, EMBASE, and the databases of the Cochrane Library. A detailed search strategy is included. All searches were limited to controlled trials and systematic reviews. No year limits were applied to the searches, but we focused on trials, guidelines, and reviews published since 2004, the year that the last review of topical antimicrobials was published in this journal. Several controlled trials demonstrate that benzoyl peroxide, topical antibiotics, and topical retinoids used in combination provide the greatest efficacy and safety profile for the treatment of mild to moderate acne, but there are few trials directly comparing different combinations of these topical therapies with one another. Additionally, robust studies comparing cost and efficacy of generic combinations of the above agents with proprietary fixed-dose combination therapies that may increase compliance are also lacking. Although they have not been extensively studied, alternative agents including dapsone, salicylic acid, azelaic acid, and zinc are safe and efficacious when combined with traditional therapies.
AB - Topical antimicrobial treatment is indicated for mild to moderate acne vulgaris. Our literature review includes searches of Ovid, MEDLINE, EMBASE, and the databases of the Cochrane Library. A detailed search strategy is included. All searches were limited to controlled trials and systematic reviews. No year limits were applied to the searches, but we focused on trials, guidelines, and reviews published since 2004, the year that the last review of topical antimicrobials was published in this journal. Several controlled trials demonstrate that benzoyl peroxide, topical antibiotics, and topical retinoids used in combination provide the greatest efficacy and safety profile for the treatment of mild to moderate acne, but there are few trials directly comparing different combinations of these topical therapies with one another. Additionally, robust studies comparing cost and efficacy of generic combinations of the above agents with proprietary fixed-dose combination therapies that may increase compliance are also lacking. Although they have not been extensively studied, alternative agents including dapsone, salicylic acid, azelaic acid, and zinc are safe and efficacious when combined with traditional therapies.
KW - Acne-vulgaris
KW - Anti-infectives
KW - Antibacterials
KW - Azelaic-acid
KW - Benzoyl-peroxide
KW - Dapsone
KW - Retinoids
KW - Salicylic-acid
KW - Topical
KW - Zinc
UR - http://www.scopus.com/inward/record.url?scp=84859394780&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84859394780&partnerID=8YFLogxK
U2 - 10.2165/11597880-000000000-00000
DO - 10.2165/11597880-000000000-00000
M3 - Review article
C2 - 22268388
AN - SCOPUS:84859394780
SN - 1175-0561
VL - 13
SP - 141
EP - 152
JO - American Journal of Clinical Dermatology
JF - American Journal of Clinical Dermatology
IS - 3
ER -