Tools for exploring mouse models of human disease

Melissa Haendel, Irene Papatheodorou, Anika Oellrich, Christopher J. Mungall, Nicole Washington, Suzanna E. Lewis, Peter N. Robinson, Damian Smedley

Research output: Contribution to journalReview articlepeer-review

Abstract

Despite significant computational challenges, a number of tools have been developed recently to leverage the mouse to model human disease. Here we review these tools and show how they can be applied in the identification of candidate genes and therapeutic targets as well as mouse models for mechanistic studies and drug validation.

Original languageEnglish (US)
Pages (from-to)21-26
Number of pages6
JournalDrug Discovery Today: Disease Models
Volume20
DOIs
StatePublished - Feb 2 2016

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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