Tools for exploring mouse models of human disease

Melissa Haendel, Irene Papatheodorou, Anika Oellrich, Christopher J. Mungall, Nicole Washington, Suzanna E. Lewis, Peter N. Robinson, Damian Smedley

Research output: Contribution to journalArticle

Abstract

Despite significant computational challenges, a number of tools have been developed recently to leverage the mouse to model human disease. Here we review these tools and show how they can be applied in the identification of candidate genes and therapeutic targets as well as mouse models for mechanistic studies and drug validation.

Original languageEnglish (US)
JournalDrug Discovery Today: Disease Models
DOIs
StateAccepted/In press - 2017

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Validation Studies
Genetic Association Studies
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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Haendel, M., Papatheodorou, I., Oellrich, A., Mungall, C. J., Washington, N., Lewis, S. E., ... Smedley, D. (Accepted/In press). Tools for exploring mouse models of human disease. Drug Discovery Today: Disease Models. https://doi.org/10.1016/j.ddmod.2017.07.004

Tools for exploring mouse models of human disease. / Haendel, Melissa; Papatheodorou, Irene; Oellrich, Anika; Mungall, Christopher J.; Washington, Nicole; Lewis, Suzanna E.; Robinson, Peter N.; Smedley, Damian.

In: Drug Discovery Today: Disease Models, 2017.

Research output: Contribution to journalArticle

Haendel, M, Papatheodorou, I, Oellrich, A, Mungall, CJ, Washington, N, Lewis, SE, Robinson, PN & Smedley, D 2017, 'Tools for exploring mouse models of human disease', Drug Discovery Today: Disease Models. https://doi.org/10.1016/j.ddmod.2017.07.004
Haendel, Melissa ; Papatheodorou, Irene ; Oellrich, Anika ; Mungall, Christopher J. ; Washington, Nicole ; Lewis, Suzanna E. ; Robinson, Peter N. ; Smedley, Damian. / Tools for exploring mouse models of human disease. In: Drug Discovery Today: Disease Models. 2017.
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