Tools for exploring mouse models of human disease

Melissa Haendel; Irene Papatheodorou; Anika Oellrich; Christopher J. Mungall; Nicole Washington; Suzanna E. Lewis; Peter N. Robinson; Damian Smedley

doi:10.1016/j.ddmod.2017.07.004

Tools for exploring mouse models of human disease

Melissa Haendel, Irene Papatheodorou, Anika Oellrich, Christopher J. Mungall, Nicole Washington, Suzanna E. Lewis, Peter N. Robinson, Damian Smedley

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Abstract

Despite significant computational challenges, a number of tools have been developed recently to leverage the mouse to model human disease. Here we review these tools and show how they can be applied in the identification of candidate genes and therapeutic targets as well as mouse models for mechanistic studies and drug validation.

Original language	English (US)
Journal	Drug Discovery Today: Disease Models
DOIs	https://doi.org/10.1016/j.ddmod.2017.07.004
State	Accepted/In press - 2017

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1016/j.ddmod.2017.07.004

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Haendel, M., Papatheodorou, I., Oellrich, A., Mungall, C. J., Washington, N., Lewis, S. E., Robinson, P. N., & Smedley, D. (Accepted/In press). Tools for exploring mouse models of human disease. Drug Discovery Today: Disease Models. https://doi.org/10.1016/j.ddmod.2017.07.004

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author = "Melissa Haendel and Irene Papatheodorou and Anika Oellrich and Mungall, {Christopher J.} and Nicole Washington and Lewis, {Suzanna E.} and Robinson, {Peter N.} and Damian Smedley",

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AU - Lewis, Suzanna E.

AU - Robinson, Peter N.

AU - Smedley, Damian

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