Tools for exploring mouse models of human disease

Melissa Haendel; Irene Papatheodorou; Anika Oellrich; Christopher J. Mungall; Nicole Washington; Suzanna E. Lewis; Peter N. Robinson; Damian Smedley

doi:10.1016/j.ddmod.2017.07.004

Tools for exploring mouse models of human disease

Melissa Haendel, Irene Papatheodorou, Anika Oellrich, Christopher J. Mungall, Nicole Washington, Suzanna E. Lewis, Peter N. Robinson, Damian Smedley

Library

Research output: Contribution to journal › Review article › peer-review

Abstract

Despite significant computational challenges, a number of tools have been developed recently to leverage the mouse to model human disease. Here we review these tools and show how they can be applied in the identification of candidate genes and therapeutic targets as well as mouse models for mechanistic studies and drug validation.

Original language	English (US)
Pages (from-to)	21-26
Number of pages	6
Journal	Drug Discovery Today: Disease Models
Volume	20
DOIs	https://doi.org/10.1016/j.ddmod.2017.07.004
State	Published - Feb 2 2016

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

Access to Document

10.1016/j.ddmod.2017.07.004

Cite this

@article{cc7b0bc1496d4a35a678914fe47e8ab3,

title = "Tools for exploring mouse models of human disease",

abstract = "Despite significant computational challenges, a number of tools have been developed recently to leverage the mouse to model human disease. Here we review these tools and show how they can be applied in the identification of candidate genes and therapeutic targets as well as mouse models for mechanistic studies and drug validation.",

author = "Melissa Haendel and Irene Papatheodorou and Anika Oellrich and Mungall, {Christopher J.} and Nicole Washington and Lewis, {Suzanna E.} and Robinson, {Peter N.} and Damian Smedley",

year = "2016",

month = feb,

day = "2",

doi = "10.1016/j.ddmod.2017.07.004",

language = "English (US)",

volume = "20",

pages = "21--26",

journal = "Drug Discovery Today: Disease Models",

issn = "1740-6757",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Tools for exploring mouse models of human disease

AU - Haendel, Melissa

AU - Papatheodorou, Irene

AU - Oellrich, Anika

AU - Mungall, Christopher J.

AU - Washington, Nicole

AU - Lewis, Suzanna E.

AU - Robinson, Peter N.

AU - Smedley, Damian

PY - 2016/2/2

Y1 - 2016/2/2

N2 - Despite significant computational challenges, a number of tools have been developed recently to leverage the mouse to model human disease. Here we review these tools and show how they can be applied in the identification of candidate genes and therapeutic targets as well as mouse models for mechanistic studies and drug validation.

AB - Despite significant computational challenges, a number of tools have been developed recently to leverage the mouse to model human disease. Here we review these tools and show how they can be applied in the identification of candidate genes and therapeutic targets as well as mouse models for mechanistic studies and drug validation.

UR - http://www.scopus.com/inward/record.url?scp=85028363418&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028363418&partnerID=8YFLogxK

U2 - 10.1016/j.ddmod.2017.07.004

DO - 10.1016/j.ddmod.2017.07.004

M3 - Review article

AN - SCOPUS:85028363418

SN - 1740-6757

VL - 20

SP - 21

EP - 26

JO - Drug Discovery Today: Disease Models

JF - Drug Discovery Today: Disease Models

ER -

Tools for exploring mouse models of human disease

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this