Tools for exploring mouse models of human disease

Melissa Haendel; Irene Papatheodorou; Anika Oellrich; Christopher J. Mungall; Nicole Washington; Suzanna E. Lewis; Peter N. Robinson; Damian Smedley

doi:10.1016/j.ddmod.2017.07.004

Tools for exploring mouse models of human disease

Melissa Haendel, Irene Papatheodorou, Anika Oellrich, Christopher J. Mungall, Nicole Washington, Suzanna E. Lewis, Peter N. Robinson, Damian Smedley

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Abstract

Despite significant computational challenges, a number of tools have been developed recently to leverage the mouse to model human disease. Here we review these tools and show how they can be applied in the identification of candidate genes and therapeutic targets as well as mouse models for mechanistic studies and drug validation.

Original language	English (US)
Pages (from-to)	21-26
Number of pages	6
Journal	Drug Discovery Today: Disease Models
Volume	20
DOIs	https://doi.org/10.1016/j.ddmod.2017.07.004
State	Published - Feb 2 2016

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1016/j.ddmod.2017.07.004

Cite this

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title = "Tools for exploring mouse models of human disease",

abstract = "Despite significant computational challenges, a number of tools have been developed recently to leverage the mouse to model human disease. Here we review these tools and show how they can be applied in the identification of candidate genes and therapeutic targets as well as mouse models for mechanistic studies and drug validation.",

author = "Melissa Haendel and Irene Papatheodorou and Anika Oellrich and Mungall, {Christopher J.} and Nicole Washington and Lewis, {Suzanna E.} and Robinson, {Peter N.} and Damian Smedley",

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AU - Haendel, Melissa

AU - Papatheodorou, Irene

AU - Oellrich, Anika

AU - Mungall, Christopher J.

AU - Washington, Nicole

AU - Lewis, Suzanna E.

AU - Robinson, Peter N.

AU - Smedley, Damian

PY - 2016/2/2

Y1 - 2016/2/2

N2 - Despite significant computational challenges, a number of tools have been developed recently to leverage the mouse to model human disease. Here we review these tools and show how they can be applied in the identification of candidate genes and therapeutic targets as well as mouse models for mechanistic studies and drug validation.

AB - Despite significant computational challenges, a number of tools have been developed recently to leverage the mouse to model human disease. Here we review these tools and show how they can be applied in the identification of candidate genes and therapeutic targets as well as mouse models for mechanistic studies and drug validation.

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DO - 10.1016/j.ddmod.2017.07.004

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EP - 26

JO - Drug Discovery Today: Disease Models

JF - Drug Discovery Today: Disease Models

SN - 1740-6757

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Tools for exploring mouse models of human disease

Abstract

ASJC Scopus subject areas

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