Tools for exploring mouse models of human disease

Melissa Haendel, Irene Papatheodorou, Anika Oellrich, Christopher J. Mungall, Nicole Washington, Suzanna E. Lewis, Peter N. Robinson, Damian Smedley

Research output: Contribution to journal › Article

Abstract

Despite significant computational challenges, a number of tools have been developed recently to leverage the mouse to model human disease. Here we review these tools and show how they can be applied in the identification of candidate genes and therapeutic targets as well as mouse models for mechanistic studies and drug validation.

Original languageEnglish (US)
JournalDrug Discovery Today: Disease Models
DOIs
StateAccepted/In press - 2017

Fingerprint

Validation Studies
Genetic Association Studies
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Cite this

Haendel, M., Papatheodorou, I., Oellrich, A., Mungall, C. J., Washington, N., Lewis, S. E., ... Smedley, D. (Accepted/In press). Tools for exploring mouse models of human disease. Drug Discovery Today: Disease Models. https://doi.org/10.1016/j.ddmod.2017.07.004

Tools for exploring mouse models of human disease. / Haendel, Melissa; Papatheodorou, Irene; Oellrich, Anika; Mungall, Christopher J.; Washington, Nicole; Lewis, Suzanna E.; Robinson, Peter N.; Smedley, Damian.

In: Drug Discovery Today: Disease Models, 2017.

Research output: Contribution to journal › Article

Haendel, M, Papatheodorou, I, Oellrich, A, Mungall, CJ, Washington, N, Lewis, SE, Robinson, PN & Smedley, D 2017, 'Tools for exploring mouse models of human disease', Drug Discovery Today: Disease Models. https://doi.org/10.1016/j.ddmod.2017.07.004
Haendel M, Papatheodorou I, Oellrich A, Mungall CJ, Washington N, Lewis SE et al. Tools for exploring mouse models of human disease. Drug Discovery Today: Disease Models. 2017. https://doi.org/10.1016/j.ddmod.2017.07.004
Haendel, Melissa ; Papatheodorou, Irene ; Oellrich, Anika ; Mungall, Christopher J. ; Washington, Nicole ; Lewis, Suzanna E. ; Robinson, Peter N. ; Smedley, Damian. / Tools for exploring mouse models of human disease. In: Drug Discovery Today: Disease Models. 2017.
@article{cc7b0bc1496d4a35a678914fe47e8ab3,
title = "Tools for exploring mouse models of human disease",
abstract = "Despite significant computational challenges, a number of tools have been developed recently to leverage the mouse to model human disease. Here we review these tools and show how they can be applied in the identification of candidate genes and therapeutic targets as well as mouse models for mechanistic studies and drug validation.",
author = "Melissa Haendel and Irene Papatheodorou and Anika Oellrich and Mungall, {Christopher J.} and Nicole Washington and Lewis, {Suzanna E.} and Robinson, {Peter N.} and Damian Smedley",
year = "2017",
doi = "10.1016/j.ddmod.2017.07.004",
language = "English (US)",
journal = "Drug Discovery Today: Disease Models",
issn = "1740-6757",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Tools for exploring mouse models of human disease

AU - Haendel, Melissa

AU - Papatheodorou, Irene

AU - Oellrich, Anika

AU - Mungall, Christopher J.

AU - Washington, Nicole

AU - Lewis, Suzanna E.

AU - Robinson, Peter N.

AU - Smedley, Damian

PY - 2017

Y1 - 2017

N2 - Despite significant computational challenges, a number of tools have been developed recently to leverage the mouse to model human disease. Here we review these tools and show how they can be applied in the identification of candidate genes and therapeutic targets as well as mouse models for mechanistic studies and drug validation.

AB - Despite significant computational challenges, a number of tools have been developed recently to leverage the mouse to model human disease. Here we review these tools and show how they can be applied in the identification of candidate genes and therapeutic targets as well as mouse models for mechanistic studies and drug validation.

UR - http://www.scopus.com/inward/record.url?scp=85028363418&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028363418&partnerID=8YFLogxK

U2 - 10.1016/j.ddmod.2017.07.004

DO - 10.1016/j.ddmod.2017.07.004

M3 - Article

AN - SCOPUS:85028363418

JO - Drug Discovery Today: Disease Models

JF - Drug Discovery Today: Disease Models

SN - 1740-6757

ER -

Access to Document