Tonic and spillover inhibition of granule cells control information flow through cerebellar cortex

Martine Hamann, David J. Rossi, David Attwell

Research output: Contribution to journalArticle

273 Citations (Scopus)

Abstract

We show that information flow through the adult cerebellar cortex, from the mossy fiber input to the Purkinje cell output, is controlled by furosemide-sensitive, diazepam- and neurosteroid-insensitive GABAA receptors on granule cells, which are activated both tonically and by GABA spillover from synaptic release sites. Tonic activation of these receptors contributes a 3-fold larger mean inhibitory conductance than GABA released synaptically by high-frequency stimulation. Tonic and spillover inhibition reduce the fraction of granule cells activated by mossy fiber input, generating an increase of coding sparseness, which is predicted to improve the information storage capacity of the cerebellum.

Original languageEnglish (US)
Pages (from-to)625-633
Number of pages9
JournalNeuron
Volume33
Issue number4
DOIs
StatePublished - Feb 14 2002
Externally publishedYes

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Cerebellar Cortex
gamma-Aminobutyric Acid
Information Storage and Retrieval
Purkinje Cells
Furosemide
GABA-A Receptors
Diazepam
Nerve Fibers
Cerebellum
Neurotransmitter Agents

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Tonic and spillover inhibition of granule cells control information flow through cerebellar cortex. / Hamann, Martine; Rossi, David J.; Attwell, David.

In: Neuron, Vol. 33, No. 4, 14.02.2002, p. 625-633.

Research output: Contribution to journalArticle

Hamann, Martine ; Rossi, David J. ; Attwell, David. / Tonic and spillover inhibition of granule cells control information flow through cerebellar cortex. In: Neuron. 2002 ; Vol. 33, No. 4. pp. 625-633.
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