Tolerance to opioids in single locus coeruleus neurons of the rat.

M. J. Christie, J. T. Williams, R. A. North

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Chronic treatment of rats with morphine caused tolerance to the membrane hyperpolarizing action of morphine in single locus coeruleus neurons in vitro. Tolerance was less pronounced for Try-D-Ala-Gly-MePhe-Gly-ol (DAGO) than for normorphine. No changes were found in affinity of naloxone for mu-receptors on these neurons, nor in the properties of the potassium conductance increase caused by mu-receptor activation. These results suggest that the mechanisms underlying tolerance involve either a reduction of the number of mu-receptors on each cell, or a reduced coupling of mu-receptors to potassium channels.

Original languageEnglish (US)
Pages (from-to)591-594
Number of pages4
JournalNIDA research monograph
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)


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