Tissue-specific regulation of the growth hormone receptor gene in streptozocin-induced diabetes in the rat

R. K. Menon, D. A. Stephan, R. I. Rao, Z. Shen-Orr, L. S. Downs, Charles Roberts, D. LeRoith, M. A. Sperling

Research output: Contribution to journalArticle

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Abstract

Abnormalities of GH secretion and clearance are well-documented in poorly controlled insulin-dependent diabetes mellitus (IDDM), but the contribution of the receptor (GHR) and the GH-binding protein (GHBP) to these abnormalities has not been defined. We studied the expression of the GHR/GHBP gene in the livers, hearts and kidneys in streptozocin-induced diabetes (STZ-D) in the rat. GHR and GHBP mRNA levels were measured by Northern blot and ribonuclease protection assays. Whereas levels of GHR and GHBP mRNA were significantly decreased in liver and heart of STZ-D rats when compared with the control group (P

Original languageEnglish (US)
Pages (from-to)453-462
Number of pages10
JournalJournal of Endocrinology
Volume142
Issue number3
StatePublished - 1994
Externally publishedYes

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Somatotropin Receptors
Experimental Diabetes Mellitus
Genes
Messenger RNA
Liver
Ribonucleases
Type 1 Diabetes Mellitus
Northern Blotting
Kidney
Control Groups
somatotropin-binding protein

ASJC Scopus subject areas

  • Endocrinology

Cite this

Menon, R. K., Stephan, D. A., Rao, R. I., Shen-Orr, Z., Downs, L. S., Roberts, C., ... Sperling, M. A. (1994). Tissue-specific regulation of the growth hormone receptor gene in streptozocin-induced diabetes in the rat. Journal of Endocrinology, 142(3), 453-462.

Tissue-specific regulation of the growth hormone receptor gene in streptozocin-induced diabetes in the rat. / Menon, R. K.; Stephan, D. A.; Rao, R. I.; Shen-Orr, Z.; Downs, L. S.; Roberts, Charles; LeRoith, D.; Sperling, M. A.

In: Journal of Endocrinology, Vol. 142, No. 3, 1994, p. 453-462.

Research output: Contribution to journalArticle

Menon, RK, Stephan, DA, Rao, RI, Shen-Orr, Z, Downs, LS, Roberts, C, LeRoith, D & Sperling, MA 1994, 'Tissue-specific regulation of the growth hormone receptor gene in streptozocin-induced diabetes in the rat', Journal of Endocrinology, vol. 142, no. 3, pp. 453-462.
Menon, R. K. ; Stephan, D. A. ; Rao, R. I. ; Shen-Orr, Z. ; Downs, L. S. ; Roberts, Charles ; LeRoith, D. ; Sperling, M. A. / Tissue-specific regulation of the growth hormone receptor gene in streptozocin-induced diabetes in the rat. In: Journal of Endocrinology. 1994 ; Vol. 142, No. 3. pp. 453-462.
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