Tissue plasminogen activator cerebrovascular thrombolysis in rabbits is dependent on the rate and route of administration

David Russell, Kenneth P. Madden, Wayne Clark, Justin A. Zivin

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background and Purpose: The main aim of our study was to assess the cerebrovascular thrombolytic efficacy of different tissue plasminogen activator treatment protocols with Doppler ultrasound. Methods: We occluded one internal carotid artery in 48 New Zealand White rabbits with whole blood emboli. Five minutes later the rabbits were assigned to receive one of the following tissue plasminogen activator protocols: 1) intravenous square-wave infusion in a total dose of 10 mg/kg, 2) intravenous constant infusion in a total dose of 10 mg/kg, 3) intravenous square-wave infusion in a total dose of 3 mg/kg, or 4) regional intra-arterial square-wave infusion in a total dose of 3 mg/kg. Blood flow velocities in the internal carotid arteries were continuously monitored during the study with Doppler ultrasound. Results: In all 12 animals treated with a 10-mg/kg square-wave intravenous tissue plasminogen infusion, internal carotid artery blood flow was reestablished within 2 hours (57.9±33.3 minutes) after the initiation of treatment, whereas this was the case for only six (50%) of the 12 animals treated with a constant 10-mg/kg intravenous tissue plasminogen activator infusion (p

Original languageEnglish (US)
Pages (from-to)388-393
Number of pages6
JournalStroke
Volume23
Issue number3
StatePublished - 1992
Externally publishedYes

Fingerprint

Internal Carotid Artery
Tissue Plasminogen Activator
Doppler Ultrasonography
Rabbits
Blood Flow Velocity
Plasminogen
Clinical Protocols
Embolism
Intravenous Infusions
Therapeutics

Keywords

  • Plasminogen activator, tissue-type
  • Rabbits
  • Ultrasonics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing
  • Neuroscience(all)

Cite this

Tissue plasminogen activator cerebrovascular thrombolysis in rabbits is dependent on the rate and route of administration. / Russell, David; Madden, Kenneth P.; Clark, Wayne; Zivin, Justin A.

In: Stroke, Vol. 23, No. 3, 1992, p. 388-393.

Research output: Contribution to journalArticle

Russell, David ; Madden, Kenneth P. ; Clark, Wayne ; Zivin, Justin A. / Tissue plasminogen activator cerebrovascular thrombolysis in rabbits is dependent on the rate and route of administration. In: Stroke. 1992 ; Vol. 23, No. 3. pp. 388-393.
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