Timing of Antiretroviral Therapy and Systemic Inflammation in Sub-Saharan Africa: Results From the META Longitudinal Cohort Study

META study investigators

Research output: Contribution to journalArticle

Abstract

Chronic inflammation predicts complications in persons with human immunodeficiency virus infection. We compared D-dimer, soluble CD14, and interleukin 6 levels before and 12 months after antiretroviral therapy (ART) initiation, among individuals starting ART during earlier-stage (CD4 T-cell count >350/µL) or late-stage disease (CD4 T-cell count <200/µL). Female sex, older age, viral load, and late-stage disease were associated with pre-ART biomarkers (n = 661; P < .05). However, there were no differences in biomarkers by disease stage after 12 months of ART (n = 438; P > .05), owing to loss from observation and greater declines in biomarkers in late-stage initiators (P < .001). Earlier initiation of ART is associated with decreased inflammation, but levels seem to converge between earlier and later initiators surviving to 12 months.

Original languageEnglish (US)
Pages (from-to)1172-1177
Number of pages6
JournalThe Journal of infectious diseases
Volume220
Issue number7
DOIs
StatePublished - Aug 30 2019

Fingerprint

Africa South of the Sahara
Longitudinal Studies
Cohort Studies
CD4 Lymphocyte Count
Inflammation
T-Lymphocytes
Virus Diseases
Interleukin-6
Therapeutics
Biomarkers
Observation
HIV

Keywords

  • antiretroviral therapy
  • HIV
  • immune activation
  • inflammation
  • South Africa
  • Uganda

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Timing of Antiretroviral Therapy and Systemic Inflammation in Sub-Saharan Africa : Results From the META Longitudinal Cohort Study. / META study investigators .

In: The Journal of infectious diseases, Vol. 220, No. 7, 30.08.2019, p. 1172-1177.

Research output: Contribution to journalArticle

@article{b5847fbe37894198950491919a03e6ac,
title = "Timing of Antiretroviral Therapy and Systemic Inflammation in Sub-Saharan Africa: Results From the META Longitudinal Cohort Study",
abstract = "Chronic inflammation predicts complications in persons with human immunodeficiency virus infection. We compared D-dimer, soluble CD14, and interleukin 6 levels before and 12 months after antiretroviral therapy (ART) initiation, among individuals starting ART during earlier-stage (CD4 T-cell count >350/µL) or late-stage disease (CD4 T-cell count <200/µL). Female sex, older age, viral load, and late-stage disease were associated with pre-ART biomarkers (n = 661; P < .05). However, there were no differences in biomarkers by disease stage after 12 months of ART (n = 438; P > .05), owing to loss from observation and greater declines in biomarkers in late-stage initiators (P < .001). Earlier initiation of ART is associated with decreased inflammation, but levels seem to converge between earlier and later initiators surviving to 12 months.",
keywords = "antiretroviral therapy, HIV, immune activation, inflammation, South Africa, Uganda",
author = "{META study investigators} and Siedner, {Mark J.} and Bwana, {Mwebesa Bosco} and Stephen Asiimwe and Gideon Amanyire and Nicholas Musinguzi and Jose Castillo-Mancilla and Tracy, {Russell P.} and Katz, {Ingrid T.} and David Bangsberg and Hunt, {Peter W.} and Catherine Orrell and Haberer, {Jessica E.}",
year = "2019",
month = "8",
day = "30",
doi = "10.1093/infdis/jiz259",
language = "English (US)",
volume = "220",
pages = "1172--1177",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "7",

}

TY - JOUR

T1 - Timing of Antiretroviral Therapy and Systemic Inflammation in Sub-Saharan Africa

T2 - Results From the META Longitudinal Cohort Study

AU - META study investigators

AU - Siedner, Mark J.

AU - Bwana, Mwebesa Bosco

AU - Asiimwe, Stephen

AU - Amanyire, Gideon

AU - Musinguzi, Nicholas

AU - Castillo-Mancilla, Jose

AU - Tracy, Russell P.

AU - Katz, Ingrid T.

AU - Bangsberg, David

AU - Hunt, Peter W.

AU - Orrell, Catherine

AU - Haberer, Jessica E.

PY - 2019/8/30

Y1 - 2019/8/30

N2 - Chronic inflammation predicts complications in persons with human immunodeficiency virus infection. We compared D-dimer, soluble CD14, and interleukin 6 levels before and 12 months after antiretroviral therapy (ART) initiation, among individuals starting ART during earlier-stage (CD4 T-cell count >350/µL) or late-stage disease (CD4 T-cell count <200/µL). Female sex, older age, viral load, and late-stage disease were associated with pre-ART biomarkers (n = 661; P < .05). However, there were no differences in biomarkers by disease stage after 12 months of ART (n = 438; P > .05), owing to loss from observation and greater declines in biomarkers in late-stage initiators (P < .001). Earlier initiation of ART is associated with decreased inflammation, but levels seem to converge between earlier and later initiators surviving to 12 months.

AB - Chronic inflammation predicts complications in persons with human immunodeficiency virus infection. We compared D-dimer, soluble CD14, and interleukin 6 levels before and 12 months after antiretroviral therapy (ART) initiation, among individuals starting ART during earlier-stage (CD4 T-cell count >350/µL) or late-stage disease (CD4 T-cell count <200/µL). Female sex, older age, viral load, and late-stage disease were associated with pre-ART biomarkers (n = 661; P < .05). However, there were no differences in biomarkers by disease stage after 12 months of ART (n = 438; P > .05), owing to loss from observation and greater declines in biomarkers in late-stage initiators (P < .001). Earlier initiation of ART is associated with decreased inflammation, but levels seem to converge between earlier and later initiators surviving to 12 months.

KW - antiretroviral therapy

KW - HIV

KW - immune activation

KW - inflammation

KW - South Africa

KW - Uganda

UR - http://www.scopus.com/inward/record.url?scp=85072056823&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072056823&partnerID=8YFLogxK

U2 - 10.1093/infdis/jiz259

DO - 10.1093/infdis/jiz259

M3 - Article

C2 - 31188451

AN - SCOPUS:85072056823

VL - 220

SP - 1172

EP - 1177

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 7

ER -