Timing of Antiretroviral Therapy and Systemic Inflammation in Sub-Saharan Africa: Results From the META Longitudinal Cohort Study

META study investigators

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Chronic inflammation predicts complications in persons with human immunodeficiency virus infection. We compared D-dimer, soluble CD14, and interleukin 6 levels before and 12 months after antiretroviral therapy (ART) initiation, among individuals starting ART during earlier-stage (CD4 T-cell count >350/µL) or late-stage disease (CD4 T-cell count <200/µL). Female sex, older age, viral load, and late-stage disease were associated with pre-ART biomarkers (n = 661; P < .05). However, there were no differences in biomarkers by disease stage after 12 months of ART (n = 438; P > .05), owing to loss from observation and greater declines in biomarkers in late-stage initiators (P < .001). Earlier initiation of ART is associated with decreased inflammation, but levels seem to converge between earlier and later initiators surviving to 12 months.

Original languageEnglish (US)
Pages (from-to)1172-1177
Number of pages6
JournalThe Journal of infectious diseases
Volume220
Issue number7
DOIs
StatePublished - Aug 30 2019

Keywords

  • antiretroviral therapy
  • HIV
  • immune activation
  • inflammation
  • South Africa
  • Uganda

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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