Time trends in biochemical recurrence after radical prostatectomy: Results of the SEARCH database

Stephen J. Freedland, Joseph C. Presti, Christopher Amling, Christopher J. Kane, William J. Aronson, Frederick Dorey, Martha K. Terris

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106 Scopus citations

Abstract

Objectives. To determine whether in the prostate-specific antigen (PSA) era stage and/or grade migration of patients treated with radical prostatectomy (RP) has occurred. We also examined whether the biochemical recurrence rates after RP have changed with time. Methods. A total of 1654 patients from the Shared Equal Access Regional Cancer Hospital (SEARCH) database were analyzed for time trends in age, preoperative PSA level, clinical stage, biopsy Gleason score, prostatectomy Gleason grade, pathologic stage, margin status, and recurrence rates after RP. Results were stratified into three 4-year blocks of time between 1988 and 2002 for analysis. Results. The preoperative PSA level, patient age, tumor stage, rate of capsular penetration, and lymph node involvement decreased with time. Both biopsy and pathologic Gleason grade steadily increased with time. The positive margin rate and incidence of seminal vesicle involvement remained stable. On multivariate analysis, only serum PSA level (P

Original languageEnglish (US)
Pages (from-to)736-741
Number of pages6
JournalUrology
Volume61
Issue number4
DOIs
Publication statusPublished - Apr 1 2003
Externally publishedYes

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ASJC Scopus subject areas

  • Urology

Cite this

Freedland, S. J., Presti, J. C., Amling, C., Kane, C. J., Aronson, W. J., Dorey, F., & Terris, M. K. (2003). Time trends in biochemical recurrence after radical prostatectomy: Results of the SEARCH database. Urology, 61(4), 736-741. https://doi.org/10.1016/S0090-4295(02)02526-8