Time-resolved photon migration in a heterogeneous tissue-vessel model

Hanli Liu; Andreas H. Hielscher; Dean C. Kurth; Steven Jacques; Britton Chance

doi:10.1117/12.209961

Time-resolved photon migration in a heterogeneous tissue-vessel model

Hanli Liu, Andreas H. Hielscher, Dean C. Kurth, Steven Jacques, Britton Chance

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Scopus citations

Abstract

We investigate the relationship between the apparent absorption coefficient and actual absorption coefficient inside the vessels. This analytical formula predicts that the apparent absorption coefficient measured on a biological organ is a volume-weighted sum of the absorption coefficients of different absorbing components. Further, we present some apparent absorption coefficients measured in vivo in animals and humans and show that ignoring the background absorption can lead to significant errors in oxygenation determination.

Original language	English (US)
Title of host publication	Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media
Subtitle of host publication	Theory, Human Studies, and Instrumentation
Editors	Britton Chance, Robert R. Alfano
Publisher	SPIE
Pages	150-156
Number of pages	7
Volume	2389
ISBN (Electronic)	9780819417367
DOIs	https://doi.org/10.1117/12.209961
State	Published - May 30 1995
Externally published	Yes
Event	Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation - San Jose, United States Duration: Feb 1 1995 → Feb 28 1995

Other

Other	Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation
Country	United States
City	San Jose
Period	2/1/95 → 2/28/95

Keywords

blood oxygenation
blood vessels
hemoglobin absorption
Heterogeneity
Me-resolved reflectance

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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Liu, H., Hielscher, A. H., Kurth, D. C., Jacques, S., & Chance, B. (1995). Time-resolved photon migration in a heterogeneous tissue-vessel model. In B. Chance, & R. R. Alfano (Eds.), Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation (Vol. 2389, pp. 150-156). SPIE. https://doi.org/10.1117/12.209961

Time-resolved photon migration in a heterogeneous tissue-vessel model. / Liu, Hanli; Hielscher, Andreas H.; Kurth, Dean C.; Jacques, Steven; Chance, Britton.

Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation. ed. / Britton Chance; Robert R. Alfano. Vol. 2389 SPIE, 1995. p. 150-156.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Liu, H, Hielscher, AH, Kurth, DC, Jacques, S & Chance, B 1995, Time-resolved photon migration in a heterogeneous tissue-vessel model. in B Chance & RR Alfano (eds), Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation. vol. 2389, SPIE, pp. 150-156, Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation, San Jose, United States, 2/1/95. https://doi.org/10.1117/12.209961

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abstract = "We investigate the relationship between the apparent absorption coefficient and actual absorption coefficient inside the vessels. This analytical formula predicts that the apparent absorption coefficient measured on a biological organ is a volume-weighted sum of the absorption coefficients of different absorbing components. Further, we present some apparent absorption coefficients measured in vivo in animals and humans and show that ignoring the background absorption can lead to significant errors in oxygenation determination.",

keywords = "blood oxygenation, blood vessels, hemoglobin absorption, Heterogeneity, Me-resolved reflectance",

author = "Hanli Liu and Hielscher, {Andreas H.} and Kurth, {Dean C.} and Steven Jacques and Britton Chance",

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AU - Liu, Hanli

AU - Hielscher, Andreas H.

AU - Kurth, Dean C.

AU - Jacques, Steven

AU - Chance, Britton

PY - 1995/5/30

Y1 - 1995/5/30

N2 - We investigate the relationship between the apparent absorption coefficient and actual absorption coefficient inside the vessels. This analytical formula predicts that the apparent absorption coefficient measured on a biological organ is a volume-weighted sum of the absorption coefficients of different absorbing components. Further, we present some apparent absorption coefficients measured in vivo in animals and humans and show that ignoring the background absorption can lead to significant errors in oxygenation determination.

AB - We investigate the relationship between the apparent absorption coefficient and actual absorption coefficient inside the vessels. This analytical formula predicts that the apparent absorption coefficient measured on a biological organ is a volume-weighted sum of the absorption coefficients of different absorbing components. Further, we present some apparent absorption coefficients measured in vivo in animals and humans and show that ignoring the background absorption can lead to significant errors in oxygenation determination.

KW - blood oxygenation

KW - blood vessels

KW - hemoglobin absorption

KW - Heterogeneity

KW - Me-resolved reflectance

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M3 - Conference contribution

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EP - 156

BT - Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media

A2 - Chance, Britton

A2 - Alfano, Robert R.

PB - SPIE

T2 - Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation

Y2 - 1 February 1995 through 28 February 1995

ER -

Time-resolved photon migration in a heterogeneous tissue-vessel model

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Keywords

ASJC Scopus subject areas

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