Time-related changes induced by zinc-deficient diet in the concentration of rat cheek epithelial membrane-coating granules

Nasser A.H. Said Al-Naief, Shahid H. Ashrafi

Research output: Contribution to journalArticle

Abstract

Weanling male Sprague-Dawley rats were fed a diet containing 0.4 parts/ 106 zinc and controls were fed an identical diet supplemented with 40 parts/ 106 zinc. After 9, 18 and 27 days of zinc deficiency, specimens were excised from cheek epithelium and processed for transmission electron microscopy to study the concentration of membrane-coating granules (MCG). Their concentration was increased in the granular-cell layers of the zinc-deficient epithelium and became significantly greater after 18 and 27 days than 9 days of deficiency. MCGs appeared in the parakeratinized layers of zinc-deficient epithelium and their concentration became significantly greater after 27 days in comparison with 9 and 18 days of deficiency. Thus the intracellular retention of MCGs was increased in the granular and parakeratinized layers with the increase in time of zinc deficiency.

Original languageEnglish (US)
Pages (from-to)717-722
Number of pages6
JournalArchives of Oral Biology
Volume40
Issue number8
DOIs
StatePublished - Aug 1995

Keywords

  • granular cells
  • keratinization
  • rat buccal cheek epithelium
  • time-related changes
  • zinc deficiency

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)
  • Cell Biology

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