Time interval between repeated injections conditions the duration of motor improvement to apomorphine in Parkinson’s disease

F. Grandas, S. Gancher, G. Lera, M. Rodriguez, William Woodward, John Nutt, J. A. Obeso

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Behavioral hyposensitivity to repeated apomorphine administration occurs in fluctuating parkinsonian patients. To determine to what extent the interval between doses influences the response, we administered equal paired apomorphine injections to 10 fluctuating parkinsonian patients. Subjects received two apomorphine injections at 2-hour and at 4-hour intervals on different days after a 10- to 12-hour overnight period without levodopa. Following apomorphine doses at 2-hour intervals, the duration of response was reduced by 40% (61 versus 42 minutes, p <0.001) but was of equal duration when the doses were given at 4-hour intervals. These findings indicate that the interval between doses is a critical determinant of motor response. We postulate a time-dependent period of partial hyposensitivity to pulsatile DA stimulation.

Original languageEnglish (US)
Pages (from-to)1287-1290
Number of pages4
JournalNeurology
Volume42
Issue number7
StatePublished - 1992

Fingerprint

Apomorphine
Parkinson Disease
Injections
Levodopa
Parkinson's Disease
Time Interval
Dose

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Time interval between repeated injections conditions the duration of motor improvement to apomorphine in Parkinson’s disease. / Grandas, F.; Gancher, S.; Lera, G.; Rodriguez, M.; Woodward, William; Nutt, John; Obeso, J. A.

In: Neurology, Vol. 42, No. 7, 1992, p. 1287-1290.

Research output: Contribution to journalArticle

Grandas, F. ; Gancher, S. ; Lera, G. ; Rodriguez, M. ; Woodward, William ; Nutt, John ; Obeso, J. A. / Time interval between repeated injections conditions the duration of motor improvement to apomorphine in Parkinson’s disease. In: Neurology. 1992 ; Vol. 42, No. 7. pp. 1287-1290.
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