Tight junctions and cell polarity

Kunyoo Shin, Vanessa C. Fogg, Ben Margolis

Research output: Contribution to journalArticle

478 Citations (Scopus)

Abstract

The tight junction is an intracellular functional structure that mediates adhesion between epithelial cells and is required for epithelial cell function. Tight junctions control paracellular permeability across epithelial cell sheets and also serve as a barrier to intramembrane diffusion of components between a cell's apical and basolateral membrane domains. Recent genetic and biochemical studies in invertebrates and vertebrates indicate that tight junction proteins play an important role in the establishment and maintenance of apico-basal polarity. Proteins involved in epithelial cell polarization form evolutionarily conserved multiprotein complexes at the tight junction, and these protein complexes regulate the architecture of epithelia throughout the polarization process. Accumulating information regarding the regulation of these polarity proteins will lead to a better understanding of the molecular mechanisms whereby cell polarity is established.

Original languageEnglish (US)
Pages (from-to)207-235
Number of pages29
JournalAnnual Review of Cell and Developmental Biology
Volume22
DOIs
StatePublished - 2006
Externally publishedYes

Fingerprint

Cell Polarity
Tight Junctions
Epithelial Cells
Tight Junction Proteins
Multiprotein Complexes
Invertebrates
Vertebrates
Molecular Biology
Permeability
Proteins
Epithelium
Maintenance
Membranes

Keywords

  • CRB complex
  • Epithelial polarity
  • Par complex
  • Tight junction proteins

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Tight junctions and cell polarity. / Shin, Kunyoo; Fogg, Vanessa C.; Margolis, Ben.

In: Annual Review of Cell and Developmental Biology, Vol. 22, 2006, p. 207-235.

Research output: Contribution to journalArticle

Shin, Kunyoo ; Fogg, Vanessa C. ; Margolis, Ben. / Tight junctions and cell polarity. In: Annual Review of Cell and Developmental Biology. 2006 ; Vol. 22. pp. 207-235.
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