Thyroxine-binding globulin deficiency detected by newborn screening

S. Mandel, Cheryl Hanna, Bruce Boston, D. Sesser, Stephen Lafranchi

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

We examined the results of the Northwest Regional Screening Program from May 1975 to June 1991 to determine the prevalence of inherited thyroxine-binding globulin (TBG) deficiency and its effect on thyroid hormone concentrations in infants. Serum thyroxine (T4), triiodothyronine resin uptake (T3RU), and thyrotropin values were requested of physicians caring for all infants with a single filter paper T4 level 4 level 4 concentration for TBG-deficient boys was 41.9 nmol/L (3.26 μg/dl); 31% had values 4 concentration for TBG-deficient girls was 60.2 nmol/L (4.68 μg/dl), with none 3RU value was 0.472 in TBG-deficient boys, and 0.412 in TBG-deficient girls; the T3RU value was >0.55 in 24% of TBG-deficient boys but was >0.55 in only one girl. Free serum T4 levels were normal in all 56 TBG-deficient infants studied, and TBG levels were low in all 20 infants studied. Inherited TBG deficiency is common in boys in the Northwest, with a frequency of 1:1700 and a male/female ratio of 8.9:1. Boys with TBG deficiency have mild, moderate, or severe alterations in total T4 and T3RU values, but severe deficiency is rare in girls.

Original languageEnglish (US)
Pages (from-to)227-230
Number of pages4
JournalJournal of Pediatrics
Volume122
Issue number2
StatePublished - 1993

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Thyroxine-Binding Globulin
Newborn Infant
Triiodothyronine
Thyrotropin
Thyroxine-Binding Globulin Deficiency
Serum
Thyroxine
Thyroid Hormones
Physicians

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Mandel, S., Hanna, C., Boston, B., Sesser, D., & Lafranchi, S. (1993). Thyroxine-binding globulin deficiency detected by newborn screening. Journal of Pediatrics, 122(2), 227-230.

Thyroxine-binding globulin deficiency detected by newborn screening. / Mandel, S.; Hanna, Cheryl; Boston, Bruce; Sesser, D.; Lafranchi, Stephen.

In: Journal of Pediatrics, Vol. 122, No. 2, 1993, p. 227-230.

Research output: Contribution to journalArticle

Mandel, S, Hanna, C, Boston, B, Sesser, D & Lafranchi, S 1993, 'Thyroxine-binding globulin deficiency detected by newborn screening', Journal of Pediatrics, vol. 122, no. 2, pp. 227-230.
Mandel S, Hanna C, Boston B, Sesser D, Lafranchi S. Thyroxine-binding globulin deficiency detected by newborn screening. Journal of Pediatrics. 1993;122(2):227-230.
Mandel, S. ; Hanna, Cheryl ; Boston, Bruce ; Sesser, D. ; Lafranchi, Stephen. / Thyroxine-binding globulin deficiency detected by newborn screening. In: Journal of Pediatrics. 1993 ; Vol. 122, No. 2. pp. 227-230.
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