Thyronamines inhibit plasma membrane and vesicular monoamine transport

Aaron N. Snead, Magda S. Santos, Rebecca P. Seal, Motonori Miyakawa, Robert H. Edwards, Thomas (Tom) Scanlan

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Abstract

Thyroid hormone has long been known to have important transcriptional regulatory activities. Recently, however, the presence of endogenous derivatives of thyroid hormone, thyronamines, has been reported in various mammalian tissues. These derivatives have potent in vitro activity with a class of orphan G-protein-coupled receptors, the trace amine-associated receptors, and profound in vivo effects when administered to mice. We report here a novel neuromodulatory role for thyronamines. In synaptosomal preparations and heterologous expression systems, thyronamines act as specific dopamine and norepinephrine reuptake inhibitors. Thyronamines also inhibit the transport of monoamines into synaptic vesicles. These observations expand the nontranscriptional role of thyroid hormone derivatives and may help to explain the pharmacological effects of thyronamines in vivo.

Original languageEnglish (US)
Pages (from-to)390-398
Number of pages9
JournalACS Chemical Biology
Volume2
Issue number6
DOIs
Publication statusPublished - Jun 2007

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine

Cite this

Snead, A. N., Santos, M. S., Seal, R. P., Miyakawa, M., Edwards, R. H., & Scanlan, T. T. (2007). Thyronamines inhibit plasma membrane and vesicular monoamine transport. ACS Chemical Biology, 2(6), 390-398. https://doi.org/10.1021/cb700057b