Thyroid hormone-sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform-specific

M. O. Ribeiro, S. D. Carvalho, J. J. Schultz, G. Chiellini, Thomas (Tom) Scanlan, A. C. Bianco, G. A. Brent

Research output: Contribution to journalArticle

188 Citations (Scopus)

Abstract

In newborns and small mammals, cold-induced adaptive (or nonshivering) thermogenesis is produced primarily in brown adipose tissue (BAT). Heat production is stimulated by the sympathetic nervous system, but it has an absolute requirement for thyroid hormone. We used the thyroid hormone receptor-β-selective (TR-β-selective) ligand, GC-1, to determine by a pharmacological approach whether adaptive thermogenesis was TR isoform-specific. Hypothyroid mice were treated for 10 days with varying doses of T3 or GC-1. The level of uncoupling protein 1 (UCP1), the key thermogenic protein in BAT, was restored by either T3 or GC-1 treatment. However, whereas interscapular BAT in T3-treated mice showed a 3.0°C elevation upon infusion of norepinephrine, indicating normal thermogenesis, the temperature did not increase (

Original languageEnglish (US)
Pages (from-to)97-105
Number of pages9
JournalJournal of Clinical Investigation
Volume108
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

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Thyroid Hormone Receptors
Thermogenesis
Thyroid Hormones
Brown Adipose Tissue
Protein Isoforms
Sympathetic Nervous System
Mammals
Norepinephrine
Pharmacology
Ligands
Temperature
GC 1 compound
Proteins

ASJC Scopus subject areas

  • Medicine(all)

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Thyroid hormone-sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform-specific. / Ribeiro, M. O.; Carvalho, S. D.; Schultz, J. J.; Chiellini, G.; Scanlan, Thomas (Tom); Bianco, A. C.; Brent, G. A.

In: Journal of Clinical Investigation, Vol. 108, No. 1, 2001, p. 97-105.

Research output: Contribution to journalArticle

Ribeiro, M. O. ; Carvalho, S. D. ; Schultz, J. J. ; Chiellini, G. ; Scanlan, Thomas (Tom) ; Bianco, A. C. ; Brent, G. A. / Thyroid hormone-sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform-specific. In: Journal of Clinical Investigation. 2001 ; Vol. 108, No. 1. pp. 97-105.
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