Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function

Guoying Yu, Argyris Tzouvelekis, Rong Wang, Jose D. Herazo-Maya, Gabriel H. Ibarra, Anup Srivastava, Joao Pedro Werneck De Castro, Giuseppe Deiuliis, Farida Ahangari, Tony Woolard, Nachelle Aurelien, Rafael Arrojo E. Drigo, Ye Gan, Morven Graham, Xinran Liu, Robert J. Homer, Thomas (Tom) Scanlan, Praveen Mannam, Patty J. Lee, Erica L. HerzogAntonio C. Bianco, Naftali Kaminski

Research output: Contribution to journalArticle

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Abstract

Thyroid hormone (TH) is critical for the maintenance of cellular homeostasis during stress responses, but its role in lung fibrosis is unknown. Here we found that the activity and expression of iodothyronine deiodinase 2 (DIO2), an enzyme that activates TH, were higher in lungs from patients with idiopathic pulmonary fibrosis than in control individuals and were correlated with disease severity. We also found that Dio2-knockout mice exhibited enhanced bleomycin-induced lung fibrosis. Aerosolized TH delivery increased survival and resolved fibrosis in two models of pulmonary fibrosis in mice (intratracheal bleomycin and inducible TGF-β1). Sobetirome, a TH mimetic, also blunted bleomycin-induced lung fibrosis. After bleomycin-induced injury, TH promoted mitochondrial biogenesis, improved mitochondrial bioenergetics and attenuated mitochondria-regulated apoptosis in alveolar epithelial cells both in vivo and in vitro. TH did not blunt fibrosis in Ppargc1a-or Pink1-knockout mice, suggesting dependence on these pathways. We conclude that the antifibrotic properties of TH are associated with protection of alveolar epithelial cells and restoration of mitochondrial function and that TH may thus represent a potential therapy for pulmonary fibrosis.

Original languageEnglish (US)
Pages (from-to)39-49
Number of pages11
JournalNature Medicine
Volume24
Issue number1
DOIs
StatePublished - Jan 1 2018

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Thyroid Hormones
Fibrosis
Lung
Bleomycin
Alveolar Epithelial Cells
Pulmonary Fibrosis
Knockout Mice
Iodide Peroxidase
Idiopathic Pulmonary Fibrosis
Mitochondria
Organelle Biogenesis
Energy Metabolism
Restoration
Homeostasis
Maintenance
Apoptosis
Survival
Wounds and Injuries
Enzymes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Yu, G., Tzouvelekis, A., Wang, R., Herazo-Maya, J. D., Ibarra, G. H., Srivastava, A., ... Kaminski, N. (2018). Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function. Nature Medicine, 24(1), 39-49. https://doi.org/10.1038/nm.4447

Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function. / Yu, Guoying; Tzouvelekis, Argyris; Wang, Rong; Herazo-Maya, Jose D.; Ibarra, Gabriel H.; Srivastava, Anup; De Castro, Joao Pedro Werneck; Deiuliis, Giuseppe; Ahangari, Farida; Woolard, Tony; Aurelien, Nachelle; Drigo, Rafael Arrojo E.; Gan, Ye; Graham, Morven; Liu, Xinran; Homer, Robert J.; Scanlan, Thomas (Tom); Mannam, Praveen; Lee, Patty J.; Herzog, Erica L.; Bianco, Antonio C.; Kaminski, Naftali.

In: Nature Medicine, Vol. 24, No. 1, 01.01.2018, p. 39-49.

Research output: Contribution to journalArticle

Yu, G, Tzouvelekis, A, Wang, R, Herazo-Maya, JD, Ibarra, GH, Srivastava, A, De Castro, JPW, Deiuliis, G, Ahangari, F, Woolard, T, Aurelien, N, Drigo, RAE, Gan, Y, Graham, M, Liu, X, Homer, RJ, Scanlan, TT, Mannam, P, Lee, PJ, Herzog, EL, Bianco, AC & Kaminski, N 2018, 'Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function', Nature Medicine, vol. 24, no. 1, pp. 39-49. https://doi.org/10.1038/nm.4447
Yu G, Tzouvelekis A, Wang R, Herazo-Maya JD, Ibarra GH, Srivastava A et al. Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function. Nature Medicine. 2018 Jan 1;24(1):39-49. https://doi.org/10.1038/nm.4447
Yu, Guoying ; Tzouvelekis, Argyris ; Wang, Rong ; Herazo-Maya, Jose D. ; Ibarra, Gabriel H. ; Srivastava, Anup ; De Castro, Joao Pedro Werneck ; Deiuliis, Giuseppe ; Ahangari, Farida ; Woolard, Tony ; Aurelien, Nachelle ; Drigo, Rafael Arrojo E. ; Gan, Ye ; Graham, Morven ; Liu, Xinran ; Homer, Robert J. ; Scanlan, Thomas (Tom) ; Mannam, Praveen ; Lee, Patty J. ; Herzog, Erica L. ; Bianco, Antonio C. ; Kaminski, Naftali. / Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function. In: Nature Medicine. 2018 ; Vol. 24, No. 1. pp. 39-49.
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