@article{09df5439fe364c31ad6a3fb4e38e0c54,
title = "Thyroid hormone and thyromimetics inhibit myelin and axonal degeneration and oligodendrocyte loss in EAE",
abstract = "We have previously demonstrated that thyromimetics stimulate oligodendrocyte precursor cell differentiation and promote remyelination in murine demyelination models. We investigated whether a thyroid receptor-beta selective thyromimetic, sobetirome (Sob), and its CNS-targeted prodrug, Sob-AM2, could prevent myelin and axonal degeneration in experimental autoimmune encephalomyelitis (EAE). Compared to controls, EAE mice receiving triiodothyronine (T3, 0.4 mg/kg), Sob (5 mg/kg) or Sob-AM2 (5 mg/kg) had reduced clinical disease and, within the spinal cord, less tissue damage, more normally myelinated axons, fewer degenerating axons and more oligodendrocytes. T3 and Sob also protected cultured oligodendrocytes against cell death. Thyromimetics thus might protect against oligodendrocyte death, demyelination and axonal degeneration as well as stimulate remyelination in multiple sclerosis.",
keywords = "EAE, Inflammation, Myelin, Oligodendrocytes, Thyromimetics",
author = "P. Chaudhary and Marracci, {G. H.} and E. Calkins and E. Pocius and Bensen, {A. L.} and Scanlan, {T. S.} and B. Emery and Bourdette, {D. N.}",
note = "Funding Information: This research was supported by the National Multiple Sclerosis Society grants RG 5199A4 and RG-1607-25053 to DB, RG 5106A1/1 to BE), the Race to Erase MS to DB, the OHSU Laura Fund for Innovation in Multiple Sclerosis to DB and TSS and NIH DK52798 to TSS. We would like to thank Advanced Light Microscopy Core and Electron Microscopy Core supported by the NIH, P30 NS061800. We would also like to thank the VA Portland Health Care System for providing animal husbandry, equipment support and laboratory space. Funding Information: This research was supported by the National Multiple Sclerosis Society grants RG 5199A4 and RG-1607-25053 to DB, RG 5106A1/1 to BE), the Race to Erase MS to DB, the OHSU Laura Fund for Innovation in Multiple Sclerosis to DB and TSS and NIH DK52798 to TSS. We would like to thank Advanced Light Microscopy Core and Electron Microscopy Core supported by the NIH , P30 NS061800 . We would also like to thank the VA Portland Health Care System for providing animal husbandry, equipment support and laboratory space. Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2021",
month = mar,
day = "15",
doi = "10.1016/j.jneuroim.2020.577468",
language = "English (US)",
volume = "352",
journal = "Advances in Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",
}