Thyroid hormone action in neural development

C. C. Thompson, Gregory Potter

Research output: Contribution to journalArticle

188 Citations (Scopus)

Abstract

Effects of thyroid hormone on development of the brain have been documented for over a century. Although in many respects the hypothyroid brain appears morphalogically normal, functional impairments include mental retardation, ataxia and spasticity. Keyed by the discovery of nuclear receptors for thyroid hormone that function as transcription factors, recent work has examined the mechanism of thyroid hormone action in brain development. The prediction that gene expression regulated by thyroid hormone is important for mediating brain development has spurred the search for thyroid hormone-responsive genes. Here we review some of the identified genes whose expression patterns correlate with the functional deficits observed in the hypothyroid brain. Recently identified thyroid hormone-responsive genes include synaptotagmin-related gene 1 (Srg1), a putative mediator of synaptic structure and/or activity, and hairless, a transcriptional cofactor that may influence the expression of other thyroid hormone-responsive genes.

Original languageEnglish (US)
Pages (from-to)939-945
Number of pages7
JournalCerebral Cortex
Volume10
Issue number10
StatePublished - 2000
Externally publishedYes

Fingerprint

Thyroid Hormones
Brain
Genes
Synaptotagmins
Gene Expression
Ataxia
Cytoplasmic and Nuclear Receptors
Intellectual Disability
Transcription Factors

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Thompson, C. C., & Potter, G. (2000). Thyroid hormone action in neural development. Cerebral Cortex, 10(10), 939-945.

Thyroid hormone action in neural development. / Thompson, C. C.; Potter, Gregory.

In: Cerebral Cortex, Vol. 10, No. 10, 2000, p. 939-945.

Research output: Contribution to journalArticle

Thompson, CC & Potter, G 2000, 'Thyroid hormone action in neural development', Cerebral Cortex, vol. 10, no. 10, pp. 939-945.
Thompson CC, Potter G. Thyroid hormone action in neural development. Cerebral Cortex. 2000;10(10):939-945.
Thompson, C. C. ; Potter, Gregory. / Thyroid hormone action in neural development. In: Cerebral Cortex. 2000 ; Vol. 10, No. 10. pp. 939-945.
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