Thyroid function in neonates of women with subclinical hypothyroidism or hypothyroxinemia

for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To assess whether treatment of pregnant women with subclinical hypothyroidism or hypothyroxinemia alters neonatal TSH results. Study design: A planned secondary analysis of data from two multi-center randomized, double-masked, placebo-controlled thyroxine replacement trials in pregnant women with either subclinical hypothyroidism or hypothyroxinemia. Infant heel-stick specimens were obtained before discharge. We compared TSH levels between neonates born to mothers allocated to treatment or placebo within each trial and between neonates in the placebo groups. Multiples of means were generated for day-of-life-specific data. Results: Neonatal TSH values were available for 573/677 (84.6%) newborns from the subclinical hypothyroidism trial and 461/526 (87.6%) newborns from the hypothyroxinemia trial. Neonatal TSH values did not differ in either trial by treatment group or between placebo groups (P > 0.05 for all comparisons). Conclusions: Neonatal TSH values did not differ with thyroid hormone replacement in pregnancies diagnosed with subclinical hypothyroidism or hypothyroxinemia.

Original languageEnglish (US)
JournalJournal of Perinatology
DOIs
StateAccepted/In press - Jan 1 2018

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Hypothyroidism
Thyroid Gland
Placebos
Newborn Infant
Pregnant Women
Heel
Thyroxine
Thyroid Hormones
Therapeutics
Mothers
Pregnancy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network (Accepted/In press). Thyroid function in neonates of women with subclinical hypothyroidism or hypothyroxinemia. Journal of Perinatology. https://doi.org/10.1038/s41372-018-0213-9

Thyroid function in neonates of women with subclinical hypothyroidism or hypothyroxinemia. / for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network.

In: Journal of Perinatology, 01.01.2018.

Research output: Contribution to journalArticle

for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network 2018, 'Thyroid function in neonates of women with subclinical hypothyroidism or hypothyroxinemia', Journal of Perinatology. https://doi.org/10.1038/s41372-018-0213-9
for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Thyroid function in neonates of women with subclinical hypothyroidism or hypothyroxinemia. Journal of Perinatology. 2018 Jan 1. https://doi.org/10.1038/s41372-018-0213-9
for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. / Thyroid function in neonates of women with subclinical hypothyroidism or hypothyroxinemia. In: Journal of Perinatology. 2018.
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abstract = "Objective: To assess whether treatment of pregnant women with subclinical hypothyroidism or hypothyroxinemia alters neonatal TSH results. Study design: A planned secondary analysis of data from two multi-center randomized, double-masked, placebo-controlled thyroxine replacement trials in pregnant women with either subclinical hypothyroidism or hypothyroxinemia. Infant heel-stick specimens were obtained before discharge. We compared TSH levels between neonates born to mothers allocated to treatment or placebo within each trial and between neonates in the placebo groups. Multiples of means were generated for day-of-life-specific data. Results: Neonatal TSH values were available for 573/677 (84.6{\%}) newborns from the subclinical hypothyroidism trial and 461/526 (87.6{\%}) newborns from the hypothyroxinemia trial. Neonatal TSH values did not differ in either trial by treatment group or between placebo groups (P > 0.05 for all comparisons). Conclusions: Neonatal TSH values did not differ with thyroid hormone replacement in pregnancies diagnosed with subclinical hypothyroidism or hypothyroxinemia.",
author = "{for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network} and Varner, {Michael W.} and Lisa Mele and Casey, {Brian M.} and Peaceman, {Alan M.} and Yoram Sorokin and Reddy, {Uma M.} and Wapner, {Ronald J.} and Thorp, {John M.} and Saade, {George R.} and Tita, {Alan T.N.} and Rouse, {Dwight J.} and Baha Sibai and Iams, {Jay D.} and Mercer, {Brian M.} and Jorge Tolosa and Caritis, {Steve N.}",
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