Thyroid function and mortality in older men: A prospective study

Avantika C. Waring, Stephanie Harrison, Mary Samuels, Kristine E. Ensrud, Erin S. LeBlanc, Andrew R. Hoffman, Eric Orwoll, Howard A. Fink, Elizabeth Barrett-Connor, Douglas C. Bauer

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Context: Mild abnormalities of thyroid function have been associated with both beneficial and detrimental effects on mortality. Objective: Our objective was to determine the association between continuous TSH as well as categories of thyroid function with total and cause-specific mortality in a cohort of older men. Design, Setting, and Participants: Data were analyzed from the Osteoporotic Fractures in Men (MrOS) study, a cohort of community-dwelling U.S. men aged 65 yr and older. A total of 1587 participants randomly selected for thyroid function testing were included in this analysis. TSH and free T 4 were measured at baseline, and four categories of thyroid function were defined. (subclinical hyperthyroid; euthyroid; subclinical hypothyroid TSH

Original languageEnglish (US)
Pages (from-to)862-870
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume97
Issue number3
DOIs
StatePublished - Mar 2012

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ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Waring, A. C., Harrison, S., Samuels, M., Ensrud, K. E., LeBlanc, E. S., Hoffman, A. R., Orwoll, E., Fink, H. A., Barrett-Connor, E., & Bauer, D. C. (2012). Thyroid function and mortality in older men: A prospective study. Journal of Clinical Endocrinology and Metabolism, 97(3), 862-870. https://doi.org/10.1210/jc.2011-2684