Thrombotic thrombocytopenic purpura in a patient with very early pregnancy: Clinical presentation and autopsy findings

Aman Sharma, Bishan Radotra, Ajay Wanchu, Pankaj Malhotra, Surjit Singh, Subhash Varma

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4 Scopus citations


Thrombotic thrombocytopenic purpura is a thrombotic microangiopathy leading to microvascular occlusion resulting in ischemic dysfunction of various organs. Pregnancy has been thought to precipitate it during second and third trimester, but its reports in first trimester are extremely rare. We report the clinical protocol of a young lady with 5-week period of gestation, who presented with fever, seizures and altered sensorium, and succumbed to her illness during an episode of seizure. Complete autopsy findings are also presented in detail.

Original languageEnglish (US)
Pages (from-to)727-730
Number of pages4
JournalBlood Coagulation and Fibrinolysis
Issue number7
Publication statusPublished - Oct 2008
Externally publishedYes


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