Thrombotic microangiopathy with intraglomerular IgM pseudothrombi in Waldenström macroglobulinemia and IgM monoclonal gammopathy

Serena Yen Shan Tan, Richard Kent Sibley, Sharina Belani, Sumie Iwasaki, Leonid Yankulin, Tracy Jonelis, John Patrick Twistington Higgins, Neeraja Kambham, Megan Troxell

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

IgM secreting myelomas or lymphomas, including Waldenström macroglobulinemia, are associated with a varied spectrum of renal pathology, including intracapillary hyaline deposits, cryoglobulin, membranoproliferative glomerulonephritis, amyloid, monoclonal immunoglobulin deposition disease, cast nephropathy, and lymphoma infiltration. We report our single institution experience, and describe five cases with distinctive glomerular pathology: intracapillary IgM pseudothrombi and thrombotic microangiopathic change, with glomerular intracellular crystals in two biopsies. Two patients were hypocomplementemic at presentation. This series adds to the recent literature on paraprotein associated thrombotic microangiopathy.

Original languageEnglish (US)
Pages (from-to)907-918
Number of pages12
JournalJournal of Nephrology
Volume31
Issue number6
DOIs
StatePublished - Dec 1 2018
Externally publishedYes

Keywords

  • Hypocomplementemia
  • IgM paraprotein
  • Thrombotic microangiopathy
  • Waldenström macroglobulinemia

ASJC Scopus subject areas

  • Nephrology

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    Tan, S. Y. S., Sibley, R. K., Belani, S., Iwasaki, S., Yankulin, L., Jonelis, T., Higgins, J. P. T., Kambham, N., & Troxell, M. (2018). Thrombotic microangiopathy with intraglomerular IgM pseudothrombi in Waldenström macroglobulinemia and IgM monoclonal gammopathy. Journal of Nephrology, 31(6), 907-918. https://doi.org/10.1007/s40620-018-0544-9