The thrombotic microangiopathies (TMs) are a group of diseases that share the qualities of thrombocytopenia and microangiopathic hemolytic anemia resulting in microvascular occlusion and end-organ damage. The classic TMs are thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). Since the early days of transplantation, it has been noted many patients developed a TM-type disease that was often fulminant and fatal. Research has been difficult due to lack of standardization of diagnostic criteria, and much controversy remains about the best therapy.
|Original language||English (US)|
|Title of host publication||Blood and Marrow Transplant Handbook|
|Subtitle of host publication||Comprehensive Guide for Patient Care|
|Publisher||Springer New York|
|Number of pages||4|
|State||Published - Dec 1 2011|
ASJC Scopus subject areas