Thrombosis in Philadelphia negative classical myeloproliferative neoplasms: a narrative review on epidemiology, risk assessment, and pathophysiologic mechanisms

Somedeb Ball, Kyaw Zin Thein, Abhishek Maiti, Kenneth Nugent

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Thrombosis is common in cancer patients and is associated with increased morbidity and mortality. Myeloproliferative neoplasms (MPN) are common malignancies in elderly individuals and are known for a high incidence of thrombotic complications. Different risk factors have been identified in studies, and risk models have been developed to identify patients with MPN at higher risk for thrombosis. Several pathophysiological mechanisms help explain the increased likelihood of thrombosis in these patients. Factors, such as leukocyte and platelet activation leading to the formation of leukocyte–platelet aggregates, activation of the coagulation cascade by microparticles, high levels of inflammatory cytokines, and endothelial dysfunction have a crucial role in thrombosis in MPN patients. Recent studies have demonstrated a significant association between the allele burden of specific genetic mutations (mainly JAK2V617F) associated with MPN and the incidence of thrombotic events, thus suggesting a possible role for these mutations in thrombogenesis.

Original languageEnglish (US)
Pages (from-to)516-528
Number of pages13
JournalJournal of Thrombosis and Thrombolysis
Volume45
Issue number4
DOIs
StatePublished - May 1 2018
Externally publishedYes

Keywords

  • Essential thrombocythemia
  • JAK2V617F mutation
  • Leukocyte activation
  • Microparticles
  • Myeloproliferative neoplasm
  • Venous thromboembolism

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

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