This chapter reviews the inherited thrombophilias, when to test for them, and what to test for. Thrombophilia is defined as a condition in which, due to an inherited or acquired disorder, there is a propensity to form thrombosis. This hypercoagulability is manifested clinically by a greater number of thromboses, thrombosis at an early age, a familial tendency toward thrombosis, or thrombosis at unusual sites. The fundamental approach is to decide whether a thrombophilia is present by the logical ordering and interpretation of tests, and then if the patient has a thrombophilia, to decide on the appropriate therapy.
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