Thrombolysis with low dose tissue plasminogen activator

E. Doyle, J. Britto, Judith (Judy) Freeman, F. Munro, N. S. Morton

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Two cases of vena caval thrombosis in infants were successfully treated with low dose (0.01-0.05 mg/kg/hour) local infusions oftissue plasminogen activator after conventional anticoagulant treatment had been unsuccessful. This approach is useful for clots associated with indwelling intravascular catheters, and a low dose infusion of tissue plasminogen activator as a regional application is recommended to achieve clot lysis with minimal systemic effects.

Original languageEnglish (US)
Pages (from-to)1483-1484
Number of pages2
JournalArchives of Disease in Childhood
Volume67
Issue number12
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Venae Cavae
Indwelling Catheters
Catheters
Plasminogen Activators
Tissue Plasminogen Activator
Anticoagulants
Thrombosis
Therapeutics

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Allergy
  • Pediatrics, Perinatology, and Child Health

Cite this

Doyle, E., Britto, J., Freeman, J. J., Munro, F., & Morton, N. S. (1992). Thrombolysis with low dose tissue plasminogen activator. Archives of Disease in Childhood, 67(12), 1483-1484. https://doi.org/10.1136/adc.67.12.1483

Thrombolysis with low dose tissue plasminogen activator. / Doyle, E.; Britto, J.; Freeman, Judith (Judy); Munro, F.; Morton, N. S.

In: Archives of Disease in Childhood, Vol. 67, No. 12, 1992, p. 1483-1484.

Research output: Contribution to journalArticle

Doyle, E, Britto, J, Freeman, JJ, Munro, F & Morton, NS 1992, 'Thrombolysis with low dose tissue plasminogen activator', Archives of Disease in Childhood, vol. 67, no. 12, pp. 1483-1484. https://doi.org/10.1136/adc.67.12.1483
Doyle, E. ; Britto, J. ; Freeman, Judith (Judy) ; Munro, F. ; Morton, N. S. / Thrombolysis with low dose tissue plasminogen activator. In: Archives of Disease in Childhood. 1992 ; Vol. 67, No. 12. pp. 1483-1484.
@article{4adbb2a06f1f4e09966e9ad7a0f09539,
title = "Thrombolysis with low dose tissue plasminogen activator",
abstract = "Two cases of vena caval thrombosis in infants were successfully treated with low dose (0.01-0.05 mg/kg/hour) local infusions oftissue plasminogen activator after conventional anticoagulant treatment had been unsuccessful. This approach is useful for clots associated with indwelling intravascular catheters, and a low dose infusion of tissue plasminogen activator as a regional application is recommended to achieve clot lysis with minimal systemic effects.",
author = "E. Doyle and J. Britto and Freeman, {Judith (Judy)} and F. Munro and Morton, {N. S.}",
year = "1992",
doi = "10.1136/adc.67.12.1483",
language = "English (US)",
volume = "67",
pages = "1483--1484",
journal = "Archives of Disease in Childhood",
issn = "0003-9888",
publisher = "BMJ Publishing Group",
number = "12",

}

TY - JOUR

T1 - Thrombolysis with low dose tissue plasminogen activator

AU - Doyle, E.

AU - Britto, J.

AU - Freeman, Judith (Judy)

AU - Munro, F.

AU - Morton, N. S.

PY - 1992

Y1 - 1992

N2 - Two cases of vena caval thrombosis in infants were successfully treated with low dose (0.01-0.05 mg/kg/hour) local infusions oftissue plasminogen activator after conventional anticoagulant treatment had been unsuccessful. This approach is useful for clots associated with indwelling intravascular catheters, and a low dose infusion of tissue plasminogen activator as a regional application is recommended to achieve clot lysis with minimal systemic effects.

AB - Two cases of vena caval thrombosis in infants were successfully treated with low dose (0.01-0.05 mg/kg/hour) local infusions oftissue plasminogen activator after conventional anticoagulant treatment had been unsuccessful. This approach is useful for clots associated with indwelling intravascular catheters, and a low dose infusion of tissue plasminogen activator as a regional application is recommended to achieve clot lysis with minimal systemic effects.

UR - http://www.scopus.com/inward/record.url?scp=0026621978&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026621978&partnerID=8YFLogxK

U2 - 10.1136/adc.67.12.1483

DO - 10.1136/adc.67.12.1483

M3 - Article

C2 - 1489229

AN - SCOPUS:0026621978

VL - 67

SP - 1483

EP - 1484

JO - Archives of Disease in Childhood

JF - Archives of Disease in Childhood

SN - 0003-9888

IS - 12

ER -