Thrombolysis with low dose tissue plasminogen activator

E. Doyle, J. Britto, J. Freeman, F. Munro, N. S. Morton

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Two cases of vena caval thrombosis in infants were successfully treated with low dose (0.01-0.05 mg/kg/hour) local infusions oftissue plasminogen activator after conventional anticoagulant treatment had been unsuccessful. This approach is useful for clots associated with indwelling intravascular catheters, and a low dose infusion of tissue plasminogen activator as a regional application is recommended to achieve clot lysis with minimal systemic effects.

Original languageEnglish (US)
Pages (from-to)1483-1484
Number of pages2
JournalArchives of Disease in Childhood
Issue number12
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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