Three-year results of a randomized prospective trial of methionyl human growth hormone and oxandrolone in Turner syndrome

Ronald (Ron) Rosenfeld, Raymond L. Hintz, Ann J. Johanson, Barry Sherman, Jo Anne Brasel, Stephen Burstein, Steven Chernausek, Peter Compton, James Frane, Ronald W. Gotlin, Joyce Kuntze, Barbara M. Lippe, Patrick C. Mahoney, Wayne V. Moore, Maria I. New, Paul Saenger, Virginia Sybert

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Abstract

Seventy girls with Turner syndrome, 4 to 12 years of age, participated in a prospective, randomized study to determine the effects on growth of methionyl human growth hormone (met-hGH) or oxandrolone. Subjects were randomly assigned to receive either no treatment (control) or met-hGH (0.125 mg/kg three times per week), oxandrolone (0.125 mg/kg/day), or combination met-hGH plus oxandrolone. At the end of an initial period of 12 to 20 months, patients in the original control and oxandrolone groups were given combination met-hGH plus oxandrolone. At that time the dosage of oxandrolone was lowered to 0.0625 mg/kg/day. Sixty-five subjects have now completed the first 3 years of the study. Compared with the control growth rate for year 1 (3.8 cm/yr), significant increases in growth rate were seen in all 3 years of combination therapy (9.8, 7.4, and 6.1 cm/yr, respectively) and in the first 2 years of treatment with met-hGH alone (6.6, 5.4, and 4.6 cm/yr). When growth velocity was expressed as standard deviation for age in girls with Turner syndrome, significant increases relative to the control group for year 1(-0.1 SD) were seen in all three years of both combination therapy and met-hGH alone (combination, +6.6, +4.3, +3.0 SD; met-hGH, +3.1, +2.0, +1.4 SD). After 3 years of treatment, predicted adult height by the method of Bayley-Pinneau increased 4.5 cm in the met-hGH group and 8.2 cm in the combination group.

Original languageEnglish (US)
Pages (from-to)393-400
Number of pages8
JournalThe Journal of Pediatrics
Volume113
Issue number2
DOIs
StatePublished - 1988
Externally publishedYes

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Oxandrolone
Turner Syndrome
Growth
Therapeutics
Control Groups
somatrem
Prospective Studies

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Rosenfeld, R. R., Hintz, R. L., Johanson, A. J., Sherman, B., Brasel, J. A., Burstein, S., ... Sybert, V. (1988). Three-year results of a randomized prospective trial of methionyl human growth hormone and oxandrolone in Turner syndrome. The Journal of Pediatrics, 113(2), 393-400. https://doi.org/10.1016/S0022-3476(88)80290-7

Three-year results of a randomized prospective trial of methionyl human growth hormone and oxandrolone in Turner syndrome. / Rosenfeld, Ronald (Ron); Hintz, Raymond L.; Johanson, Ann J.; Sherman, Barry; Brasel, Jo Anne; Burstein, Stephen; Chernausek, Steven; Compton, Peter; Frane, James; Gotlin, Ronald W.; Kuntze, Joyce; Lippe, Barbara M.; Mahoney, Patrick C.; Moore, Wayne V.; New, Maria I.; Saenger, Paul; Sybert, Virginia.

In: The Journal of Pediatrics, Vol. 113, No. 2, 1988, p. 393-400.

Research output: Contribution to journalArticle

Rosenfeld, RR, Hintz, RL, Johanson, AJ, Sherman, B, Brasel, JA, Burstein, S, Chernausek, S, Compton, P, Frane, J, Gotlin, RW, Kuntze, J, Lippe, BM, Mahoney, PC, Moore, WV, New, MI, Saenger, P & Sybert, V 1988, 'Three-year results of a randomized prospective trial of methionyl human growth hormone and oxandrolone in Turner syndrome', The Journal of Pediatrics, vol. 113, no. 2, pp. 393-400. https://doi.org/10.1016/S0022-3476(88)80290-7
Rosenfeld, Ronald (Ron) ; Hintz, Raymond L. ; Johanson, Ann J. ; Sherman, Barry ; Brasel, Jo Anne ; Burstein, Stephen ; Chernausek, Steven ; Compton, Peter ; Frane, James ; Gotlin, Ronald W. ; Kuntze, Joyce ; Lippe, Barbara M. ; Mahoney, Patrick C. ; Moore, Wayne V. ; New, Maria I. ; Saenger, Paul ; Sybert, Virginia. / Three-year results of a randomized prospective trial of methionyl human growth hormone and oxandrolone in Turner syndrome. In: The Journal of Pediatrics. 1988 ; Vol. 113, No. 2. pp. 393-400.
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abstract = "Seventy girls with Turner syndrome, 4 to 12 years of age, participated in a prospective, randomized study to determine the effects on growth of methionyl human growth hormone (met-hGH) or oxandrolone. Subjects were randomly assigned to receive either no treatment (control) or met-hGH (0.125 mg/kg three times per week), oxandrolone (0.125 mg/kg/day), or combination met-hGH plus oxandrolone. At the end of an initial period of 12 to 20 months, patients in the original control and oxandrolone groups were given combination met-hGH plus oxandrolone. At that time the dosage of oxandrolone was lowered to 0.0625 mg/kg/day. Sixty-five subjects have now completed the first 3 years of the study. Compared with the control growth rate for year 1 (3.8 cm/yr), significant increases in growth rate were seen in all 3 years of combination therapy (9.8, 7.4, and 6.1 cm/yr, respectively) and in the first 2 years of treatment with met-hGH alone (6.6, 5.4, and 4.6 cm/yr). When growth velocity was expressed as standard deviation for age in girls with Turner syndrome, significant increases relative to the control group for year 1(-0.1 SD) were seen in all three years of both combination therapy and met-hGH alone (combination, +6.6, +4.3, +3.0 SD; met-hGH, +3.1, +2.0, +1.4 SD). After 3 years of treatment, predicted adult height by the method of Bayley-Pinneau increased 4.5 cm in the met-hGH group and 8.2 cm in the combination group.",
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AU - Sherman, Barry

AU - Brasel, Jo Anne

AU - Burstein, Stephen

AU - Chernausek, Steven

AU - Compton, Peter

AU - Frane, James

AU - Gotlin, Ronald W.

AU - Kuntze, Joyce

AU - Lippe, Barbara M.

AU - Mahoney, Patrick C.

AU - Moore, Wayne V.

AU - New, Maria I.

AU - Saenger, Paul

AU - Sybert, Virginia

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N2 - Seventy girls with Turner syndrome, 4 to 12 years of age, participated in a prospective, randomized study to determine the effects on growth of methionyl human growth hormone (met-hGH) or oxandrolone. Subjects were randomly assigned to receive either no treatment (control) or met-hGH (0.125 mg/kg three times per week), oxandrolone (0.125 mg/kg/day), or combination met-hGH plus oxandrolone. At the end of an initial period of 12 to 20 months, patients in the original control and oxandrolone groups were given combination met-hGH plus oxandrolone. At that time the dosage of oxandrolone was lowered to 0.0625 mg/kg/day. Sixty-five subjects have now completed the first 3 years of the study. Compared with the control growth rate for year 1 (3.8 cm/yr), significant increases in growth rate were seen in all 3 years of combination therapy (9.8, 7.4, and 6.1 cm/yr, respectively) and in the first 2 years of treatment with met-hGH alone (6.6, 5.4, and 4.6 cm/yr). When growth velocity was expressed as standard deviation for age in girls with Turner syndrome, significant increases relative to the control group for year 1(-0.1 SD) were seen in all three years of both combination therapy and met-hGH alone (combination, +6.6, +4.3, +3.0 SD; met-hGH, +3.1, +2.0, +1.4 SD). After 3 years of treatment, predicted adult height by the method of Bayley-Pinneau increased 4.5 cm in the met-hGH group and 8.2 cm in the combination group.

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