TY - JOUR
T1 - Three-Dimensional Augmented Reality Visualization Informs Locoregional Therapy in a Translational Model of Hepatocellular Carcinoma
AU - Park, Brian J.
AU - Perkons, Nicholas R.
AU - Profka, Enri
AU - Johnson, Omar
AU - Morley, Christopher
AU - Appel, Scott
AU - Nadolski, Gregory J.
AU - Hunt, Stephen J.
AU - Gade, Terence P.
N1 - Funding Information:
B.P. received grants from the National Institutes of Health ( 5T32EB004311 ), Society of Interventional Radiology Foundation , and Radiological Society of North America Research and Education Foundation . The authors thank the Penn Medicine Medical Device Accelerator for supporting equipment for this research.
Funding Information:
B.P. received grants from the National Institutes of Health (5T32EB004311), Society of Interventional Radiology Foundation, and Radiological Society of North America Research and Education Foundation. The authors thank the Penn Medicine Medical Device Accelerator for supporting equipment for this research. B.J.P. receives grants from Nvidia (Santa Clara, California). C.M. is the founder and chief operating officer of Medivis (Brooklyn, New York). None of the other authors have identified a conflict of interest.
Publisher Copyright:
© 2020 SIR
PY - 2020/10
Y1 - 2020/10
N2 - Purpose: To evaluate the utility of visualizing preprocedural MR images in 3-dimensional (3D) space using augmented reality (AR) before transarterial embolization of hepatocellular carcinoma (HCC) in a preclinical model. Materials and Methods: A total of 28 rats with diethylnitrosamine-induced HCCs > 5 mm treated with embolization were included in a prospective study. In 12 rats, 3D AR visualization of preprocedural MR images was performed before embolization. Procedural metrics including catheterization time and radiation exposure were compared vs a prospective cohort of 16 rats in which embolization was performed without AR. An additional cohort of 15 retrospective cases was identified and combined with the prospective control cohort (n = 31) to improve statistical power. Results: A 37% reduction in fluoroscopy time, from 11.7 min to 7.4 minutes, was observed with AR when compared prospectively, which did not reach statistical significance (P = .12); however, when compared with combined prospective and retrospective controls, the reduction in fluoroscopy time from 14.1 min to 7.4 minutes (48%) was significant (P = .01). A 27% reduction in total catheterization time, from 42.7 minutes to 31.0 minutes, was also observed with AR when compared prospectively, which did not reach statistical significance (P = .11). No significant differences were seen in dose–area product or air kerma prospectively. Conclusions: Three-dimensional AR visualization of preprocedural imaging may aid in the reduction of procedural metrics in a preclinical model of transarterial embolization. These data support the need for further studies to evaluate the potential of AR in endovascular oncologic interventions.
AB - Purpose: To evaluate the utility of visualizing preprocedural MR images in 3-dimensional (3D) space using augmented reality (AR) before transarterial embolization of hepatocellular carcinoma (HCC) in a preclinical model. Materials and Methods: A total of 28 rats with diethylnitrosamine-induced HCCs > 5 mm treated with embolization were included in a prospective study. In 12 rats, 3D AR visualization of preprocedural MR images was performed before embolization. Procedural metrics including catheterization time and radiation exposure were compared vs a prospective cohort of 16 rats in which embolization was performed without AR. An additional cohort of 15 retrospective cases was identified and combined with the prospective control cohort (n = 31) to improve statistical power. Results: A 37% reduction in fluoroscopy time, from 11.7 min to 7.4 minutes, was observed with AR when compared prospectively, which did not reach statistical significance (P = .12); however, when compared with combined prospective and retrospective controls, the reduction in fluoroscopy time from 14.1 min to 7.4 minutes (48%) was significant (P = .01). A 27% reduction in total catheterization time, from 42.7 minutes to 31.0 minutes, was also observed with AR when compared prospectively, which did not reach statistical significance (P = .11). No significant differences were seen in dose–area product or air kerma prospectively. Conclusions: Three-dimensional AR visualization of preprocedural imaging may aid in the reduction of procedural metrics in a preclinical model of transarterial embolization. These data support the need for further studies to evaluate the potential of AR in endovascular oncologic interventions.
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U2 - 10.1016/j.jvir.2020.01.028
DO - 10.1016/j.jvir.2020.01.028
M3 - Article
C2 - 32826152
AN - SCOPUS:85089531675
VL - 31
SP - 1612-1618.e1
JO - Journal of Vascular and Interventional Radiology
JF - Journal of Vascular and Interventional Radiology
SN - 1051-0443
IS - 10
ER -