Thoracic manifestations of systemic autoimmune diseases: Radiographic and high-resolution CT findings

Jennifer P. Mayberry, Steven L. Primack, Nestor L. Müller

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


The systemic autoimmune diseases include collagen vascular diseases, the systemic vasculitides, Wegener granulomatosis, and Churg-Strauss syndrome. They can cause a variety of thoracic abnormalities that are influenced by the pathophysiologic characteristics of the underlying disease process. Although many of the abnormalities can be detected at chest radiography, high-resolution computed tomography (CT) has been shown to be superior in depicting parenchymal, airway, and pleural abnormalities. Thoracic manifestations of collagen vascular diseases include pleural disease, pulmonary fibrosis, diaphragm weakness, aspiration pneumonia, bronchiolitis obliterans organizing pneumonia, bronchiolitis obliterans, and bronchiectasis. Wegener granulomatosis may be associated with multiple nodules or masses with irregular margins that are frequently cavitated. Patients with Churg-Strauss syndrome often have consolidation or ground-glass attenuation at chest radiography and CT. Goodpasture syndrome is associated with extensive bilateral air-space consolidation.

Original languageEnglish (US)
Pages (from-to)1623-1635
Number of pages13
Issue number6
StatePublished - 2000


  • Arthritis, rheumatoid, 60.611
  • Dermatomyositis, 60.614
  • Lung, CT, 60.12118
  • Lung, diseases, 60.61, 60.62, 60.691, 60.695
  • Lupus erythematosus, 60.612
  • Scleroderma, 60.613
  • Spondylitis, 60.74
  • Wegener granulomatosis, 60.622

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Thoracic manifestations of systemic autoimmune diseases: Radiographic and high-resolution CT findings'. Together they form a unique fingerprint.

Cite this