Thermally sensitive fluorescence imaging system for radiofrequency ablation guidance

Xiaoxia Guo, Yongkang Gai, Fang Du, Qingbing Wang, Lingyi Sun, Xiaoyi Ding, Dexing Zeng, Zhiyuan Wu

Research output: Contribution to journalArticle

Abstract

Radiofrequency ablation (RFA) has been clinically used as a minimally invasive procedure for the treatment of many solid tumors. However, the current imaging techniques have some shortages in RFA guidance, especially for the assessment of the margin of ablation. Herein, we developed a novel optical imaging platform to guide RFA utilizing fluorescence resonance energy transfer from a thermally sensitive fluorescent protein conjugated to a near-infrared fluorescent dye. Additionally, attaching receptor-targeting ligands further equipped the system with high specificity to tumors overexpressing the targeted receptor.

Original languageEnglish (US)
Pages (from-to)308-315
Number of pages8
JournalInternational Journal of Hyperthermia
Volume37
Issue number1
DOIs
StatePublished - Jan 1 2020

Keywords

  • Fluorescence imaging
  • cancer
  • fluorescence resonance energy transfer
  • radiofrequency ablation
  • thermally sensitive

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Cancer Research

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