Thermal injury: Defects in immune response induction

Carol L. Miller, Donald Trunkey

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

The immunocompetence of leukocyte subpopulations from mice which had received a 10% scald burn has been examined following injury. Leukocytes from the burned animals were reduced 80% in their ability to generate de novo antibody-forming cells in vitro. When leukocytes from the injured animals were supplied with the immunologically active factors produced by normal A and T leukocytes, their immunocompetence was restored. These experiments indicate that: (i) Thermal injury directly reduces the immune activity of leukocytes; (ii) the thermal-induced leukocyte injury is time dependent; and (iii) the leukocyte subpopulation affected is not the antibody-forming B cell.

Original languageEnglish (US)
Pages (from-to)621-625
Number of pages5
JournalJournal of Surgical Research
Volume22
Issue number6
DOIs
Publication statusPublished - 1977
Externally publishedYes

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ASJC Scopus subject areas

  • Surgery

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