Thermal injury

Defects in immune response induction

Carol L. Miller, Donald Trunkey

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The immunocompetence of leukocyte subpopulations from mice which had received a 10% scald burn has been examined following injury. Leukocytes from the burned animals were reduced 80% in their ability to generate de novo antibody-forming cells in vitro. When leukocytes from the injured animals were supplied with the immunologically active factors produced by normal A and T leukocytes, their immunocompetence was restored. These experiments indicate that: (i) Thermal injury directly reduces the immune activity of leukocytes; (ii) the thermal-induced leukocyte injury is time dependent; and (iii) the leukocyte subpopulation affected is not the antibody-forming B cell.

Original languageEnglish (US)
Pages (from-to)621-625
Number of pages5
JournalJournal of Surgical Research
Volume22
Issue number6
DOIs
StatePublished - 1977
Externally publishedYes

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Leukocytes
Hot Temperature
Wounds and Injuries
Immunocompetence
Antibodies
B-Lymphocytes

ASJC Scopus subject areas

  • Surgery

Cite this

Thermal injury : Defects in immune response induction. / Miller, Carol L.; Trunkey, Donald.

In: Journal of Surgical Research, Vol. 22, No. 6, 1977, p. 621-625.

Research output: Contribution to journalArticle

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