Thermal coagulation of tissues. Liver studies indicate a distribution of rate parameters, not a single rate parameter, describes the coagulation process

Steven L. Jacques, Carl Newman, Xiao Yan He

Research output: Chapter in Book/Report/Conference proceedingConference contribution

22 Scopus citations

Abstract

Application of kinetic theory to the process of irreversible thermal denaturation of a biomolecule describes the transformation from a native form A to a denatured form B using a temperature-dependent first-order rate constant, k, in units of s-1. Thermal coagulation in tissues involves irreversible aggregation of denatured biomolecules and may be treated with this simple single-parameter kinetic theory. We present studies in pig liver which document changes in optical scattering as a quantitative measure of coagulation. The results indicate that a distribution of k parameters, not a single k parameter, is needed to describe liver coagulation. The practical implications are that thermal coagulation of liver begins faster than and finishes slower than the predictions based on a single parameter process.

Original languageEnglish (US)
Title of host publicationAdvances in Biological Heat and Mass Transfer
PublisherPubl by ASME
Pages71-73
Number of pages3
ISBN (Print)0791808785
StatePublished - Dec 1 1991
EventWinter Annual Meeting of the American Society of Mechanical Engineers - Atlanta, GA, USA
Duration: Dec 1 1991Dec 6 1991

Publication series

NameAmerican Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD
Volume189
ISSN (Print)0272-5673

Other

OtherWinter Annual Meeting of the American Society of Mechanical Engineers
CityAtlanta, GA, USA
Period12/1/9112/6/91

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ASJC Scopus subject areas

  • Mechanical Engineering
  • Fluid Flow and Transfer Processes

Cite this

Jacques, S. L., Newman, C., & He, X. Y. (1991). Thermal coagulation of tissues. Liver studies indicate a distribution of rate parameters, not a single rate parameter, describes the coagulation process. In Advances in Biological Heat and Mass Transfer (pp. 71-73). (American Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD; Vol. 189). Publ by ASME.