Therapy-related B-lymphoblastic leukemia associated with Philadelphia chromosome and MLL rearrangement

Single institution experience and the review of the literature

Rahul Matnani, Vishwas Parekh, Uma Borate, Jason Brazelton, Vishnu Reddy, Deniz Peker

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Therapy related acute lymphoblastic leukemia (t-ALL) of B cell origin is rare and constitutes approximately 2% of all ALL. Previously compiled data on the complete cytogenetic analysis of 48 t-B-ALL cases suggested that MLL rearrangement at 11q23 gene locus is the most common abnormality. Philadelphia chromosome (Ph) and a normal karyotype were reported as the second and third most common karyotypes, respectively. We investigated cytogenetic karyotypes of six t-B-ALL cases with a pre-B cell immunophenotype. Ph + t-B-ALL was noted in four of six patients previously treated with radiation and/or chemotherapy. In addition, one case demonstrated MLL rearrangement at 11q23 locus while one case demonstrated normal cytogenetic karyotype. Five of the six t-B-ALL patients had persistent leukemia following initiation of chemotherapy for secondary leukemia with survival ranging from 10 to 21 months. To our knowledge, only fourteen patients with Ph + t-B-ALL have been described in the literature. In the current study, three of four cases with Ph + t-B-ALL were associated with treated breast carcinoma while one patient was treated for Hodgkin lymphoma. All four patients had undergone radiation therapy. The results may indicate a plausible association between Ph+t-B-ALL and prior radiation exposure.

Original languageEnglish (US)
Pages (from-to)536-540
Number of pages5
JournalPathology International
Volume65
Issue number10
DOIs
StatePublished - Oct 1 2015
Externally publishedYes

Fingerprint

Philadelphia Chromosome
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Karyotype
Cytogenetics
Leukemia
Therapeutics
Drug Therapy
B-Lymphoid Precursor Cells
Cytogenetic Analysis
Hodgkin Disease
B-Lymphocytes
Radiotherapy
Radiation
Breast Neoplasms
Survival
Genes

Keywords

  • B-ALL
  • MLL
  • Philadelphia chromosome
  • Therapy-related

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Therapy-related B-lymphoblastic leukemia associated with Philadelphia chromosome and MLL rearrangement : Single institution experience and the review of the literature. / Matnani, Rahul; Parekh, Vishwas; Borate, Uma; Brazelton, Jason; Reddy, Vishnu; Peker, Deniz.

In: Pathology International, Vol. 65, No. 10, 01.10.2015, p. 536-540.

Research output: Contribution to journalArticle

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