Therapy-related B-lymphoblastic leukemia associated with Philadelphia chromosome and MLL rearrangement: Single institution experience and the review of the literature

Rahul Matnani, Vishwas Parekh, Uma Borate, Jason Brazelton, Vishnu Reddy, Deniz Peker

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Therapy related acute lymphoblastic leukemia (t-ALL) of B cell origin is rare and constitutes approximately 2% of all ALL. Previously compiled data on the complete cytogenetic analysis of 48 t-B-ALL cases suggested that MLL rearrangement at 11q23 gene locus is the most common abnormality. Philadelphia chromosome (Ph) and a normal karyotype were reported as the second and third most common karyotypes, respectively. We investigated cytogenetic karyotypes of six t-B-ALL cases with a pre-B cell immunophenotype. Ph + t-B-ALL was noted in four of six patients previously treated with radiation and/or chemotherapy. In addition, one case demonstrated MLL rearrangement at 11q23 locus while one case demonstrated normal cytogenetic karyotype. Five of the six t-B-ALL patients had persistent leukemia following initiation of chemotherapy for secondary leukemia with survival ranging from 10 to 21 months. To our knowledge, only fourteen patients with Ph + t-B-ALL have been described in the literature. In the current study, three of four cases with Ph + t-B-ALL were associated with treated breast carcinoma while one patient was treated for Hodgkin lymphoma. All four patients had undergone radiation therapy. The results may indicate a plausible association between Ph+t-B-ALL and prior radiation exposure.

Original languageEnglish (US)
Pages (from-to)536-540
Number of pages5
JournalPathology International
Volume65
Issue number10
DOIs
StatePublished - Oct 1 2015
Externally publishedYes

Fingerprint

Philadelphia Chromosome
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Karyotype
Cytogenetics
Leukemia
Therapeutics
Drug Therapy
B-Lymphoid Precursor Cells
Cytogenetic Analysis
Hodgkin Disease
B-Lymphocytes
Radiotherapy
Radiation
Breast Neoplasms
Survival
Genes

Keywords

  • B-ALL
  • MLL
  • Philadelphia chromosome
  • Therapy-related

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Therapy-related B-lymphoblastic leukemia associated with Philadelphia chromosome and MLL rearrangement : Single institution experience and the review of the literature. / Matnani, Rahul; Parekh, Vishwas; Borate, Uma; Brazelton, Jason; Reddy, Vishnu; Peker, Deniz.

In: Pathology International, Vol. 65, No. 10, 01.10.2015, p. 536-540.

Research output: Contribution to journalArticle

@article{3466ebbaebaa4eaa9426a5608aabd15b,
title = "Therapy-related B-lymphoblastic leukemia associated with Philadelphia chromosome and MLL rearrangement: Single institution experience and the review of the literature",
abstract = "Therapy related acute lymphoblastic leukemia (t-ALL) of B cell origin is rare and constitutes approximately 2{\%} of all ALL. Previously compiled data on the complete cytogenetic analysis of 48 t-B-ALL cases suggested that MLL rearrangement at 11q23 gene locus is the most common abnormality. Philadelphia chromosome (Ph) and a normal karyotype were reported as the second and third most common karyotypes, respectively. We investigated cytogenetic karyotypes of six t-B-ALL cases with a pre-B cell immunophenotype. Ph + t-B-ALL was noted in four of six patients previously treated with radiation and/or chemotherapy. In addition, one case demonstrated MLL rearrangement at 11q23 locus while one case demonstrated normal cytogenetic karyotype. Five of the six t-B-ALL patients had persistent leukemia following initiation of chemotherapy for secondary leukemia with survival ranging from 10 to 21 months. To our knowledge, only fourteen patients with Ph + t-B-ALL have been described in the literature. In the current study, three of four cases with Ph + t-B-ALL were associated with treated breast carcinoma while one patient was treated for Hodgkin lymphoma. All four patients had undergone radiation therapy. The results may indicate a plausible association between Ph+t-B-ALL and prior radiation exposure.",
keywords = "B-ALL, MLL, Philadelphia chromosome, Therapy-related",
author = "Rahul Matnani and Vishwas Parekh and Uma Borate and Jason Brazelton and Vishnu Reddy and Deniz Peker",
year = "2015",
month = "10",
day = "1",
doi = "10.1111/pin.12337",
language = "English (US)",
volume = "65",
pages = "536--540",
journal = "Pathology International",
issn = "1320-5463",
publisher = "Wiley-Blackwell",
number = "10",

}

TY - JOUR

T1 - Therapy-related B-lymphoblastic leukemia associated with Philadelphia chromosome and MLL rearrangement

T2 - Single institution experience and the review of the literature

AU - Matnani, Rahul

AU - Parekh, Vishwas

AU - Borate, Uma

AU - Brazelton, Jason

AU - Reddy, Vishnu

AU - Peker, Deniz

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Therapy related acute lymphoblastic leukemia (t-ALL) of B cell origin is rare and constitutes approximately 2% of all ALL. Previously compiled data on the complete cytogenetic analysis of 48 t-B-ALL cases suggested that MLL rearrangement at 11q23 gene locus is the most common abnormality. Philadelphia chromosome (Ph) and a normal karyotype were reported as the second and third most common karyotypes, respectively. We investigated cytogenetic karyotypes of six t-B-ALL cases with a pre-B cell immunophenotype. Ph + t-B-ALL was noted in four of six patients previously treated with radiation and/or chemotherapy. In addition, one case demonstrated MLL rearrangement at 11q23 locus while one case demonstrated normal cytogenetic karyotype. Five of the six t-B-ALL patients had persistent leukemia following initiation of chemotherapy for secondary leukemia with survival ranging from 10 to 21 months. To our knowledge, only fourteen patients with Ph + t-B-ALL have been described in the literature. In the current study, three of four cases with Ph + t-B-ALL were associated with treated breast carcinoma while one patient was treated for Hodgkin lymphoma. All four patients had undergone radiation therapy. The results may indicate a plausible association between Ph+t-B-ALL and prior radiation exposure.

AB - Therapy related acute lymphoblastic leukemia (t-ALL) of B cell origin is rare and constitutes approximately 2% of all ALL. Previously compiled data on the complete cytogenetic analysis of 48 t-B-ALL cases suggested that MLL rearrangement at 11q23 gene locus is the most common abnormality. Philadelphia chromosome (Ph) and a normal karyotype were reported as the second and third most common karyotypes, respectively. We investigated cytogenetic karyotypes of six t-B-ALL cases with a pre-B cell immunophenotype. Ph + t-B-ALL was noted in four of six patients previously treated with radiation and/or chemotherapy. In addition, one case demonstrated MLL rearrangement at 11q23 locus while one case demonstrated normal cytogenetic karyotype. Five of the six t-B-ALL patients had persistent leukemia following initiation of chemotherapy for secondary leukemia with survival ranging from 10 to 21 months. To our knowledge, only fourteen patients with Ph + t-B-ALL have been described in the literature. In the current study, three of four cases with Ph + t-B-ALL were associated with treated breast carcinoma while one patient was treated for Hodgkin lymphoma. All four patients had undergone radiation therapy. The results may indicate a plausible association between Ph+t-B-ALL and prior radiation exposure.

KW - B-ALL

KW - MLL

KW - Philadelphia chromosome

KW - Therapy-related

UR - http://www.scopus.com/inward/record.url?scp=84942826764&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84942826764&partnerID=8YFLogxK

U2 - 10.1111/pin.12337

DO - 10.1111/pin.12337

M3 - Article

C2 - 26259760

AN - SCOPUS:84942826764

VL - 65

SP - 536

EP - 540

JO - Pathology International

JF - Pathology International

SN - 1320-5463

IS - 10

ER -