Therapeutic trials for low back pain

Richard M. Hoffman, Judith A. Turner, Daniel C. Cherkin, Richard A. Deyo, Larry D. Herron

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Little consensus exists regarding the indications for and effectiveness of many back pain treatments. This clinical uncertainty arises because most back pain research has been flawed by poor methodology. The authors discuss strategies for improving the quality of back pain research on treatrrent efficacy, Design features, including randomized treatment allocation, independent outcome assessors, comprehensive outcome measures, appropriate statistical analyses, and close patient follow-up can Increase study validity. Complete descriptions of enrollment criteria, patient characteristics, and clinical interventions can increase the generalizability of results. Although large scale trials often involve university centers, community-based researchers can collaborate on randomized trials or conduct valuable cohort studies.

Original languageEnglish (US)
Pages (from-to)2068-2075
Number of pages8
Issue number18
StatePublished - Sep 1994
Externally publishedYes


  • Health status measures
  • Low back pain
  • Randomized trials
  • Spine surgery
  • Study design

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Clinical Neurology


Dive into the research topics of 'Therapeutic trials for low back pain'. Together they form a unique fingerprint.

Cite this