Therapeutic efficacy of 5-FU bletilla striata microspheres infused through hepatic artery against rabbit VX2 transplanted hepatoma

Xin Li, Gan Sheng Feng, Chuan Shen Zhen, Xi Liu, Jian Kong

Research output: Contribution to journalArticle

Abstract

AIM: To observe the therapeutic efficacy of 5-FU bletilla striata microspheres inFUsed through hepatic artery against rabbit VX2 transplanted hepatoma. METHODS: Fifty rabbits bearing VX2 transplanted hepatoma were randomly divided into five groups (n = 10). Normal saline 1 mL, 5-Fu solutions 1 mL, ultr-liquor-lipiodol 0.3-0.4 mL and 5-Fu solutions 1 mL, 100 g/L Bletillaolloid 0.4 mL and 5-Fu solutions 1 mL, 5 FU-bletilla striate microspheres 10 mg/kg were infused though hepatic artery respectively. The tumor growth rates, necrosis rates and hepatic function were compared among the 5 groups. RESULTS: 5-FU bletilla striata microspheres had a very good vessel embolization function. In 5FU-bletilla striata microspheres group, the tumor was significantly inhibited, tumor growth rate was lower than tant in the control group (P < 0.01) and the lipiodol group (P < 0.05). Tumor necrosis grades were also more higher compared with to the other 4 groups. Complete necrosis was found in 2 of 10 rabbits in 5FU-bletilla striata microspheres group, which was more severe than that in the lipiodol group and bletillaolloid group. But the damage of normal liver tissues was also more serious. CONCLUSION: 5-FU bletilla striata microsphere is a safe and effective peripheral embolization agent.

Original languageEnglish (US)
Pages (from-to)1337-1340
Number of pages4
JournalWorld Chinese Journal of Digestology
Volume11
Issue number9
StatePublished - Sep 1 2003

ASJC Scopus subject areas

  • Gastroenterology

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