TY - JOUR
T1 - Theory, methods, and operational results of the Young Women’s Health History Study
T2 - a study of young-onset breast cancer incidence in Black and White women
AU - Velie, Ellen M.
AU - Marcus, Lydia R.
AU - Pathak, Dorothy R.
AU - Hamilton, Ann S.
AU - DiGaetano, Ralph
AU - Klinger, Ron
AU - Gollapudi, Bibi
AU - Houang, Richard
AU - Carnegie, Nicole
AU - Olson, L. Karl
AU - Allen, Amani
AU - Zhang, Zhenzhen
AU - Modjesk, Denise
AU - Norman, Gwendolyn
AU - Lucas, Darek R.
AU - Gupta, Sapna
AU - Rui, Hallgeir
AU - Schwartz, Kendra
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/10
Y1 - 2021/10
N2 - Purpose: The etiology of young-onset breast cancer (BC) is poorly understood, despite its greater likelihood of being hormone receptor-negative with a worse prognosis and persistent racial and socioeconomic inequities. We conducted a population-based case–control study of BC among young Black and White women and here discuss the theory that informed our study, exposures collected, study methods, and operational results. Methods: Cases were non-Hispanic Black (NHB) and White (NHW) women age 20–49 years with invasive BC in metropolitan Detroit and Los Angeles County SEER registries 2010–2015. Controls were identified through area-based sampling from the U.S. census and frequency matched to cases on study site, race, and age. An eco-social theory of health informed life-course exposures collected from in-person interviews, including socioeconomic, reproductive, and energy balance factors. Measured anthropometry, blood (or saliva), and among cases SEER tumor characteristics and tumor tissue (from a subset of cases) were also collected. Results: Of 5,309 identified potentially eligible cases, 2,720 sampled participants were screened and 1,812 completed interviews (682 NHB, 1140 NHW; response rate (RR): 60%). Of 24,612 sampled control households 18,612 were rostered, 2,716 participants were sampled and screened, and 1,381 completed interviews (665 NHB, 716 NHW; RR: 53%). Ninety-nine% of participants completed the main interview, 82% provided blood or saliva (75% blood only), and SEER tumor characteristics (including ER, PR and HER2 status) were obtained from 96% of cases. Conclusions: Results from the successfully established YWHHS should expand our understanding of young-onset BC etiology overall and by tumor type and identify sources of racial and socioeconomic inequities in BC.
AB - Purpose: The etiology of young-onset breast cancer (BC) is poorly understood, despite its greater likelihood of being hormone receptor-negative with a worse prognosis and persistent racial and socioeconomic inequities. We conducted a population-based case–control study of BC among young Black and White women and here discuss the theory that informed our study, exposures collected, study methods, and operational results. Methods: Cases were non-Hispanic Black (NHB) and White (NHW) women age 20–49 years with invasive BC in metropolitan Detroit and Los Angeles County SEER registries 2010–2015. Controls were identified through area-based sampling from the U.S. census and frequency matched to cases on study site, race, and age. An eco-social theory of health informed life-course exposures collected from in-person interviews, including socioeconomic, reproductive, and energy balance factors. Measured anthropometry, blood (or saliva), and among cases SEER tumor characteristics and tumor tissue (from a subset of cases) were also collected. Results: Of 5,309 identified potentially eligible cases, 2,720 sampled participants were screened and 1,812 completed interviews (682 NHB, 1140 NHW; response rate (RR): 60%). Of 24,612 sampled control households 18,612 were rostered, 2,716 participants were sampled and screened, and 1,381 completed interviews (665 NHB, 716 NHW; RR: 53%). Ninety-nine% of participants completed the main interview, 82% provided blood or saliva (75% blood only), and SEER tumor characteristics (including ER, PR and HER2 status) were obtained from 96% of cases. Conclusions: Results from the successfully established YWHHS should expand our understanding of young-onset BC etiology overall and by tumor type and identify sources of racial and socioeconomic inequities in BC.
KW - Breast cancer
KW - Epidemiology
KW - Health status disparities
KW - Life-course
KW - Premenopause
KW - Young-onset breast cancer
UR - http://www.scopus.com/inward/record.url?scp=85111106933&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85111106933&partnerID=8YFLogxK
U2 - 10.1007/s10552-021-01461-x
DO - 10.1007/s10552-021-01461-x
M3 - Article
C2 - 34292440
AN - SCOPUS:85111106933
SN - 0957-5243
VL - 32
SP - 1129
EP - 1148
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 10
ER -