Theodore E. Woodward award: cardiovascular complications of cocaine abuse.

Richard A. Lange, Joaquin Cigarroa, L. David Hillis

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

As cocaine abuse has become widespread, it has been associated with various cardiovascular complications, including angina pectoris, myocardial infarction, and sudden cardiac death. Cocaine's principal effects on the cardiovascular system are mediated via alpha-adrenergic stimulation and include (a) an increase in the determinants of myocardial oxygen demand (heart rate and systemic arterial pressure) and (b) a concomitant decrease in myocardial oxygen supply (caused by vasoconstriction of the epicardial coronary arteries). Cocaine-induced coronary arterial vasoconstriction is enhanced at sites of atherosclerotic narrowing. Delayed or recurrent vasoconstriction of the coronary arteries may occur hours after the serum cocaine concentration has declined and appears to be caused by cocaine's major metabolites. Beta-adrenergic blocking agents may exacerbate cocaine-induced coronary arterial vasoconstriction, thereby increasing the magnitude of myocardial ischemia. Concomitant cigarette smoking exacerbates the deleterious effects of cocaine on myocardial oxygen supply and demand substantially.

Original languageEnglish (US)
JournalTransactions of the American Clinical and Climatological Association
Volume115
StatePublished - 2004
Externally publishedYes

Fingerprint

Cocaine-Related Disorders
Cocaine
Vasoconstriction
Oxygen
Coronary Vessels
Adrenergic beta-Antagonists
Sudden Cardiac Death
Angina Pectoris
Cardiovascular System
Adrenergic Agents
Myocardial Ischemia
Arterial Pressure
Heart Rate
Smoking
Myocardial Infarction
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Theodore E. Woodward award : cardiovascular complications of cocaine abuse. / Lange, Richard A.; Cigarroa, Joaquin; Hillis, L. David.

In: Transactions of the American Clinical and Climatological Association, Vol. 115, 2004.

Research output: Contribution to journalArticle

@article{9b63045a4579473ab70fef49ba3cdca7,
title = "Theodore E. Woodward award: cardiovascular complications of cocaine abuse.",
abstract = "As cocaine abuse has become widespread, it has been associated with various cardiovascular complications, including angina pectoris, myocardial infarction, and sudden cardiac death. Cocaine's principal effects on the cardiovascular system are mediated via alpha-adrenergic stimulation and include (a) an increase in the determinants of myocardial oxygen demand (heart rate and systemic arterial pressure) and (b) a concomitant decrease in myocardial oxygen supply (caused by vasoconstriction of the epicardial coronary arteries). Cocaine-induced coronary arterial vasoconstriction is enhanced at sites of atherosclerotic narrowing. Delayed or recurrent vasoconstriction of the coronary arteries may occur hours after the serum cocaine concentration has declined and appears to be caused by cocaine's major metabolites. Beta-adrenergic blocking agents may exacerbate cocaine-induced coronary arterial vasoconstriction, thereby increasing the magnitude of myocardial ischemia. Concomitant cigarette smoking exacerbates the deleterious effects of cocaine on myocardial oxygen supply and demand substantially.",
author = "Lange, {Richard A.} and Joaquin Cigarroa and Hillis, {L. David}",
year = "2004",
language = "English (US)",
volume = "115",
journal = "Transactions of the American Clinical and Climatological Association",
issn = "0065-7778",
publisher = "American Clinical And Climatological Association",

}

TY - JOUR

T1 - Theodore E. Woodward award

T2 - cardiovascular complications of cocaine abuse.

AU - Lange, Richard A.

AU - Cigarroa, Joaquin

AU - Hillis, L. David

PY - 2004

Y1 - 2004

N2 - As cocaine abuse has become widespread, it has been associated with various cardiovascular complications, including angina pectoris, myocardial infarction, and sudden cardiac death. Cocaine's principal effects on the cardiovascular system are mediated via alpha-adrenergic stimulation and include (a) an increase in the determinants of myocardial oxygen demand (heart rate and systemic arterial pressure) and (b) a concomitant decrease in myocardial oxygen supply (caused by vasoconstriction of the epicardial coronary arteries). Cocaine-induced coronary arterial vasoconstriction is enhanced at sites of atherosclerotic narrowing. Delayed or recurrent vasoconstriction of the coronary arteries may occur hours after the serum cocaine concentration has declined and appears to be caused by cocaine's major metabolites. Beta-adrenergic blocking agents may exacerbate cocaine-induced coronary arterial vasoconstriction, thereby increasing the magnitude of myocardial ischemia. Concomitant cigarette smoking exacerbates the deleterious effects of cocaine on myocardial oxygen supply and demand substantially.

AB - As cocaine abuse has become widespread, it has been associated with various cardiovascular complications, including angina pectoris, myocardial infarction, and sudden cardiac death. Cocaine's principal effects on the cardiovascular system are mediated via alpha-adrenergic stimulation and include (a) an increase in the determinants of myocardial oxygen demand (heart rate and systemic arterial pressure) and (b) a concomitant decrease in myocardial oxygen supply (caused by vasoconstriction of the epicardial coronary arteries). Cocaine-induced coronary arterial vasoconstriction is enhanced at sites of atherosclerotic narrowing. Delayed or recurrent vasoconstriction of the coronary arteries may occur hours after the serum cocaine concentration has declined and appears to be caused by cocaine's major metabolites. Beta-adrenergic blocking agents may exacerbate cocaine-induced coronary arterial vasoconstriction, thereby increasing the magnitude of myocardial ischemia. Concomitant cigarette smoking exacerbates the deleterious effects of cocaine on myocardial oxygen supply and demand substantially.

UR - http://www.scopus.com/inward/record.url?scp=37049003698&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37049003698&partnerID=8YFLogxK

M3 - Article

C2 - 17060960

AN - SCOPUS:37049003698

VL - 115

JO - Transactions of the American Clinical and Climatological Association

JF - Transactions of the American Clinical and Climatological Association

SN - 0065-7778

ER -