The Zebrafish as a Genetic Model to Study Otolith Formation

Christian Söllner, Teresa Nicolson

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations

Abstract

Taken together, the results from studies in zebrafish and studies in other fish species and mammals provide a more comprehensive picture of otolith or otoconia formation. During the first phase of otolith development, the presence of glycogenous otolithic seeding particles is crucial for the formation of the otoliths. Prior to the attachment of these seeding particles to the kinocilia of the tether cells, matrix proteins involved in otolith formation are already associated with seeding particles (Figure 14.5b). These otolithic seeding particles probably provide the correct microenvironments for the process of calcium carbonate nucleation. Either the seeding particles themselves or matrix proteins associated with the particles such as collagens or acidic proteins like Starmaker may facilitate this process.

Original languageEnglish (US)
Title of host publicationBiomineralization
Subtitle of host publicationProgress in Biology, Molecular Biology and Application
PublisherWiley-Blackwell
Pages229-242
Number of pages14
ISBN (Electronic)9783527604135
ISBN (Print)9783527310654
DOIs
StatePublished - Jul 22 2005

ASJC Scopus subject areas

  • Chemistry(all)

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  • Cite this

    Söllner, C., & Nicolson, T. (2005). The Zebrafish as a Genetic Model to Study Otolith Formation. In Biomineralization: Progress in Biology, Molecular Biology and Application (pp. 229-242). Wiley-Blackwell. https://doi.org/10.1002/3527604138.ch14