TY - JOUR
T1 - The wolf in sheep's clothing
T2 - the role of interleukin-6 in immunity, inflammation and cancer
AU - Naugler, Willscott E.
AU - Karin, Michael
PY - 2008/3
Y1 - 2008/3
N2 - Recent discoveries involving the cytokine interleukin (IL)-6 have originated from diverse disciplines, revealing roles in biological processes that are likewise varied. The most novel findings suggest a connection between inflammation and diseases, such as insulin resistance associated with diabetes mellitus and cancer, which had not or only weakly been appreciated previously. The IL-6 pathway is one of the mechanisms linking inflammation to these disease processes. In addition, new evidence points toward IL-6 as one of the mediators coordinating the interface between adaptive and innate immunity. Here, we review the evidence linking IL-6 to inflammatory diseases and cancer.
AB - Recent discoveries involving the cytokine interleukin (IL)-6 have originated from diverse disciplines, revealing roles in biological processes that are likewise varied. The most novel findings suggest a connection between inflammation and diseases, such as insulin resistance associated with diabetes mellitus and cancer, which had not or only weakly been appreciated previously. The IL-6 pathway is one of the mechanisms linking inflammation to these disease processes. In addition, new evidence points toward IL-6 as one of the mediators coordinating the interface between adaptive and innate immunity. Here, we review the evidence linking IL-6 to inflammatory diseases and cancer.
UR - http://www.scopus.com/inward/record.url?scp=40649109728&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=40649109728&partnerID=8YFLogxK
U2 - 10.1016/j.molmed.2007.12.007
DO - 10.1016/j.molmed.2007.12.007
M3 - Review article
C2 - 18261959
AN - SCOPUS:40649109728
SN - 1471-4914
VL - 14
SP - 109
EP - 119
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 3
ER -