The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer

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Abstract

Recent discoveries involving the cytokine interleukin (IL)-6 have originated from diverse disciplines, revealing roles in biological processes that are likewise varied. The most novel findings suggest a connection between inflammation and diseases, such as insulin resistance associated with diabetes mellitus and cancer, which had not or only weakly been appreciated previously. The IL-6 pathway is one of the mechanisms linking inflammation to these disease processes. In addition, new evidence points toward IL-6 as one of the mediators coordinating the interface between adaptive and innate immunity. Here, we review the evidence linking IL-6 to inflammatory diseases and cancer.

Original languageEnglish (US)
Pages (from-to)109-119
Number of pages11
JournalTrends in Molecular Medicine
Volume14
Issue number3
DOIs
StatePublished - Mar 2008

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Immunity
Interleukin-6
Inflammation
Neoplasms
Biological Phenomena
Adaptive Immunity
Innate Immunity
Insulin Resistance
Diabetes Mellitus
Cytokines

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The wolf in sheep's clothing : the role of interleukin-6 in immunity, inflammation and cancer. / Naugler, Willscott (Scott); Karin, Michael.

In: Trends in Molecular Medicine, Vol. 14, No. 3, 03.2008, p. 109-119.

Research output: Contribution to journalArticle

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