TY - JOUR
T1 - The viral infectivity factor (Vif) of HIV-1 unveiled
AU - Rose, Kristine M.
AU - Marin, Mariana
AU - Kozak, Susan L.
AU - Kabat, David
N1 - Funding Information:
Our work on Vif and in preparation of this manuscript were supported by NIH grant AI49729 from the US Public Health Service.
PY - 2004/6/1
Y1 - 2004/6/1
N2 - The viral infectivity factor (Vif) of HIV type-1 (HIV-1) is essential for efficient viral replication, yet was, until recently, enigmatic. This resulted from the complexity and cellular specificity of its function and the correspondingly complex systems that are required for its investigation. These limitations have been overcome and Vif function has been rapidly elucidated, with implications for the development of drugs to block its activity. These studies have revealed a novel component of the innate immune system, APOBEC3G, that lethally hypermutates retroviruses, including HIV-1. For HIV-1, the competition between the virus and APOBEC3G is tipped in favor of the invader by Vif, which binds to APOBEC3G and triggers its polyubiquitination and rapid degradation, thereby preventing its entry into progeny virions.
AB - The viral infectivity factor (Vif) of HIV type-1 (HIV-1) is essential for efficient viral replication, yet was, until recently, enigmatic. This resulted from the complexity and cellular specificity of its function and the correspondingly complex systems that are required for its investigation. These limitations have been overcome and Vif function has been rapidly elucidated, with implications for the development of drugs to block its activity. These studies have revealed a novel component of the innate immune system, APOBEC3G, that lethally hypermutates retroviruses, including HIV-1. For HIV-1, the competition between the virus and APOBEC3G is tipped in favor of the invader by Vif, which binds to APOBEC3G and triggers its polyubiquitination and rapid degradation, thereby preventing its entry into progeny virions.
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U2 - 10.1016/j.molmed.2004.04.008
DO - 10.1016/j.molmed.2004.04.008
M3 - Review article
C2 - 15177194
AN - SCOPUS:2642511413
SN - 1471-4914
VL - 10
SP - 291
EP - 297
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 6
ER -