The vasodilatory actions of insulin on resistance and terminal arterioles and their impact on muscle glucose uptake

Lucy H. Clerk, Michelle A. Vincent, Jonathan R. Lindner, Michael G. Clark, Stephen Rattigan, Eugene J. Barrett

    Research output: Contribution to journalReview article

    84 Scopus citations

    Abstract

    Whether a discrete vascular action of insulin in skeletal muscle integrally participates in insulin-mediated glucose disposal has been extensively examined but remains a contentious issue. Here, we review some of the data both supporting and questioning the role of insulin-mediated increases in limb blood flow in glucose metabolism. We advance the hypothesis that controversy has arisen, at least in part, from a failure to recognize that insulin exerts at least three separate actions on the peripheral vasculature, each with its own characteristic dose and time responsiveness. We summarize how, viewed in this manner, certain points of contention can be resolved. We also advance the hypothesis that an action on the precapillary arteriole may play the dominant role in mediating perfusion-dependent effects of insulin on glucose metabolism in muscle.

    Original languageEnglish (US)
    Pages (from-to)3-12
    Number of pages10
    JournalDiabetes/Metabolism Research and Reviews
    Volume20
    Issue number1
    DOIs
    StatePublished - Jan 2004

    Keywords

    • 1-methylxanthine
    • Capillary recruitment
    • Contrast ultrasound
    • Insulin sensitivity
    • Muscle blood flow
    • Nitric oxide synthase

    ASJC Scopus subject areas

    • Internal Medicine
    • Endocrinology, Diabetes and Metabolism
    • Endocrinology

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