The value of traditional upper endoscopy as a diagnostic test for Barrett's esophagus

Amy Wang, Nora C. Mattek, Christopher Corless, David Lieberman, Glenn M. Eisen

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: The standard test for diagnosing Barrett's esophagus (BE) is a conventional upper endoscopy. However, studies have shown that confirmation of BE by endoscopy with histologic intestinal metaplasia can be difficult. Objective: To determine the overall accuracy, as well as factors that influence the accuracy of a conventional upper endoscopy in diagnosing BE. Setting: Thirteen academic, community, and Veterans Affairs sites. Design: A retrospective data review. Patients: Patients who underwent an upper endoscopy with a finding of "suspected Barrett's esophagus" and esophageal biopsies. Pathology reports were examined to identify cases with intestinal metaplasia. Main Outcome Measurements: Percentage of pathology-confirmed BE among suspected cases. Results: A total of 2511 procedures were examined; the frequency of biopsy-confirmed BE was 48.4%. Multivariate logistic regression identified the following factors to be independently associated with biopsy-confirmed BE: long-segment BE that measured ≥3 cm (odds ratio [OR] 4.61 [95% CI, 3.73-5.69]), male sex (OR 1.82 [95% CI, 1.49-2.22]), increasing age (age interval 70-79 years with OR 2.33 compared with age

Original languageEnglish (US)
Pages (from-to)859-866
Number of pages8
JournalGastrointestinal Endoscopy
Volume68
Issue number5
DOIs
StatePublished - Nov 2008

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Barrett Esophagus
Routine Diagnostic Tests
Endoscopy
Odds Ratio
Metaplasia
Biopsy
Pathology
Sex Ratio
Veterans
Logistic Models

ASJC Scopus subject areas

  • Gastroenterology
  • Radiology Nuclear Medicine and imaging

Cite this

The value of traditional upper endoscopy as a diagnostic test for Barrett's esophagus. / Wang, Amy; Mattek, Nora C.; Corless, Christopher; Lieberman, David; Eisen, Glenn M.

In: Gastrointestinal Endoscopy, Vol. 68, No. 5, 11.2008, p. 859-866.

Research output: Contribution to journalArticle

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