The use of live three-dimensional Doppler echocardiography in the measurement of cardiac output: An in vivo animal study

James Pemberton, Xiaokui Li, Tara Karamlou, Chloe A. Sandquist, Karl Thiele, Irving Shen, Ross M. Ungerleider, Antoinette Kenny, David Sahn

Research output: Contribution to journalArticle

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Abstract

The purpose of this study was to investigate whether cardiac output (CO) could be accurately computed from live three-dimensional (3-D) Doppler echocardiographic data in an acute open-chested animal preparation. The accurate measurement of CO is important in both patient management and research. Current methods use invasive pulmonary artery catheters or two-dimensional (2-D) echocardiography or esophageal aortic Doppler measures, with the inherent risks and inaccuracies of these techniques. Seventeen juvenile, open-chested pigs were studied before undergoing a separate cardiopulmonary bypass procedure. Live 3-D Doppler echocardiography images of the left ventricular outflow tract and aortic valve were obtained by epicardial scanning, using a Philips Medical Systems (Andover, Massachusetts) Sonos 7500 Live 3-D Echo system with a 2.5-MHz probe. Simultaneous CO measurements were obtained from an ultrasonic flow probe placed around the aortic root. Subsequent offline processing using custom software computed the CO from the digital 3-D Doppler DICOM data, and this was compared to the gold standard of the aortic flow probe measurements. One hundred forty-three individual CO measurements were taken from 16 pigs, one being excluded because of severe aortic regurgitation. There was good correlation between the 3-D Doppler and flow probe methods of CO measurement (y = 1.1x - 9.82, R 2 = 0.93). In this acute animal preparation, live 3-D Doppler echocardiographic data allowed for accurate assessment of CO as compared to the ultrasonic flow probe measurement.

Original languageEnglish (US)
Pages (from-to)433-438
Number of pages6
JournalJournal of the American College of Cardiology
Volume45
Issue number3
DOIs
StatePublished - Feb 1 2005

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Three-Dimensional Echocardiography
Doppler Echocardiography
Cardiac Output
Ultrasonics
Swine
Thorax
Aortic Valve Insufficiency
Cardiopulmonary Bypass
Aortic Valve
Pulmonary Artery
Echocardiography
Software
Catheters
Research

ASJC Scopus subject areas

  • Nursing(all)

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The use of live three-dimensional Doppler echocardiography in the measurement of cardiac output : An in vivo animal study. / Pemberton, James; Li, Xiaokui; Karamlou, Tara; Sandquist, Chloe A.; Thiele, Karl; Shen, Irving; Ungerleider, Ross M.; Kenny, Antoinette; Sahn, David.

In: Journal of the American College of Cardiology, Vol. 45, No. 3, 01.02.2005, p. 433-438.

Research output: Contribution to journalArticle

Pemberton, James ; Li, Xiaokui ; Karamlou, Tara ; Sandquist, Chloe A. ; Thiele, Karl ; Shen, Irving ; Ungerleider, Ross M. ; Kenny, Antoinette ; Sahn, David. / The use of live three-dimensional Doppler echocardiography in the measurement of cardiac output : An in vivo animal study. In: Journal of the American College of Cardiology. 2005 ; Vol. 45, No. 3. pp. 433-438.
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