The unmet need in rheumatology: Reports from the targeted therapies meeting 2017

Kevin L. Winthrop, Vibeke Strand, Désirée van der Heijde, Philip Mease, Mary Crow, Michael Weinblatt, Joan Bathon, Gerd R. Burmester, Maxime Dougados, Johnathan Kay, Xavier Mariette, Ronald Van Vollenhoven, Joachim Sieper, Fritz Melchers, Ferdinand C. Breedfeld, Joachim Kalden, Josef S. Smolen, Daniel E. Furst

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The 19th annual international Targeted Therapies meeting brought together over 100 leading basic scientists and clinical researchers from around the world in the field of immunology, molecular biology and rheumatology and other specialties. During the meeting, breakout sessions were held consisting of 5 disease-specific groups with 20–40 experts assigned to each group based on clinical or scientific expertise. Specific groups included: rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, systemic lupus erythematous, connective tissue diseases (e.g. Sjogren's syndrome, Systemic sclerosis, vasculitis including Bechet's and IgG4 related disease), and a basic science immunology group spanning all of the above clinical domains. In each group, experts were asked to consider and update previously identified unmet needs in 3 categorical areas: basic/translational science, clinical science and therapeutic development, and clinical care. Overall, similar primary unmet needs were identified within each disease foci, and several additional needs were identified since the time of last year's congress. Within translational/basic science, the need for better understanding the heterogeneity within each disease was highlighted so that predictive tools for therapeutic responses can be developed. Within clinical science and therapeutic trials, a strong focus was placed upon the need to identify pre-clinical states of disease allowing prevention in those at risk. The ability to cure remains perhaps the ultimate unmet need. Further, the need to develop new and affordable therapeutics, as well as to conduct strategic trials of currently approved therapies was again highlighted. Within the clinical care realm, improved co-morbidity management and patient-centered care were identified as unmet needs. Lastly, it was strongly felt there was a need to develop a scientific infrastructure for well-characterized, longitudinal cohorts paired with biobanks and mechanisms to support data-sharing. This infrastructure could facilitate many of the unmet needs identified within each disease area.

Original languageEnglish (US)
Pages (from-to)87-93
Number of pages7
JournalClinical Immunology
Volume186
DOIs
StatePublished - Jan 2018

Keywords

  • Ankylosing spondylitis
  • Inflammatory myopathies
  • Psoriatic arthritis
  • Rheumatoid arthritis
  • Sjögren's syndrome
  • Spondyloarthritis
  • Systemic lupus erythematosus
  • Systemic sclerosis
  • Vasculitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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  • Cite this

    Winthrop, K. L., Strand, V., van der Heijde, D., Mease, P., Crow, M., Weinblatt, M., Bathon, J., Burmester, G. R., Dougados, M., Kay, J., Mariette, X., Van Vollenhoven, R., Sieper, J., Melchers, F., Breedfeld, F. C., Kalden, J., Smolen, J. S., & Furst, D. E. (2018). The unmet need in rheumatology: Reports from the targeted therapies meeting 2017. Clinical Immunology, 186, 87-93. https://doi.org/10.1016/j.clim.2017.08.009